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Gene and Protein Information  |
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| Frizzled family G protein-coupled receptor | ||||||
| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | 7 | 585 | 2q33.3 | FZD5 | frizzled class receptor 5 | 10 |
| Mouse | 7 | 585 | 1 32.74 cM | Fzd5 | frizzled class receptor 5 | |
| Rat | 7 | 585 | 9q32 | Fzd5 | frizzled class receptor 5 | |
| Previous and Unofficial Names |
| frizzled family receptor 5 | Fz5 |
| Database Links |
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| Alphafold | Q13467 (Hs), Q9EQD0 (Mm), Q8CHL0 (Rn) |
| CATH/Gene3D | 1.10.2000.10 |
| ChEMBL Target | CHEMBL3559687 (Hs) |
| Ensembl Gene | ENSG00000163251 (Hs), ENSMUSG00000045005 (Mm), ENSRNOG00000014678 (Rn) |
| Entrez Gene | 7855 (Hs), 14367 (Mm), 317674 (Rn) |
| Human Protein Atlas | ENSG00000163251 (Hs) |
| KEGG Gene | hsa:7855 (Hs), mmu:14367 (Mm), rno:317674 (Rn) |
| OMIM | 601723 (Hs) |
| Pharos | Q13467 (Hs) |
| RefSeq Nucleotide | NM_003468 (Hs), NM_022721 (Mm), NM_173838 (Rn) |
| RefSeq Protein | NP_003459 (Hs), NP_073558 (Mm), NP_776210 (Rn) |
| UniProtKB | Q13467 (Hs), Q9EQD0 (Mm), Q8CHL0 (Rn) |
| Wikipedia | FZD5 (Hs) |
| Natural/Endogenous Ligands |
| WNTs |
Download all structure-activity data for this target as a CSV file 
| Agonist Comments | ||
| WNT-3A, WNT-5A and WNT-7A have been shown to bind to the FZD5 receptor using immunoprecipitation. Due to the lack of purified and biologically active WNTs hardly any information on the specificity and pharmacology of FZD-WNT interaction is available. Extensive and quantitative binding assays have not been performed with mammalian FZDs. For further information see [3]. |
| Antibodies | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Antibody Comments | |||||||||||||||||||||||||||||||||||||||||||||||||||
| IgG-2919 and IgG-2921 are FZD5 antibodies that have exhibited antitumour activities in vitro and in vivo (inhibiting the growth of RNF43-mutant pancreatic ductal adenocarcinoma cells/xenograft tumours), by blocking autocrine Wnt-β-catenin signalling in these mutant, FZD5-dependent cells [12]. | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Immuno Process Associations | ||
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| Primary Transduction Mechanisms
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| Transducer | Effector/Response |
| Gq/G11 family | |
| Comments: Signal transduction involving G proteins is likely [6]. | |
| References: 16 | |
| Secondary Transduction Mechanisms |
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| Comments: FZD/beta-catenin signalling (also referred to as canonical WNT signalling) [13]. | |
| References: |
| Tissue Distribution
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| Expression Datasets |
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| Functional Assays
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| Physiological Functions
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| Phenotypes, Alleles and Disease Models
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Mouse data from MGI | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Clinically-Relevant Mutations and Pathophysiology
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1. Borello U, Buffa V, Sonnino C, Melchionna R, Vivarelli E, Cossu G. (1999) Differential expression of the Wnt putative receptors Frizzled during mouse somitogenesis. Mech Dev, 89 (1-2): 173-7. [PMID:10559494]
2. Dickins EM, Salinas PC. (2013) Wnts in action: from synapse formation to synaptic maintenance. Front Cell Neurosci, 7: 162. [PMID:24223536]
3. Dijksterhuis JP, Petersen J, Schulte G. (2013) WNT/Frizzled signaling: receptor-ligand selectivity with focus on FZD-G protein signaling and its physiological relevance. Br J Pharmacol,. [PMID:24032637]
4. Gurney A, Axelrod F, Bond CJ, Cain J, Chartier C, Donigan L, Fischer M, Chaudhari A, Ji M, Kapoun AM et al.. (2012) Wnt pathway inhibition via the targeting of Frizzled receptors results in decreased growth and tumorigenicity of human tumors. Proc Natl Acad Sci USA, 109 (29): 11717-22. [PMID:22753465]
5. Ishikawa T, Tamai Y, Zorn AM, Yoshida H, Seldin MF, Nishikawa S, Taketo MM. (2001) Mouse Wnt receptor gene Fzd5 is essential for yolk sac and placental angiogenesis. Development, 128 (1): 25-33. [PMID:11092808]
6. Kilander MB, Dijksterhuis JP, Ganji RS, Bryja V, Schulte G. (2011) WNT-5A stimulates the GDP/GTP exchange at pertussis toxin-sensitive heterotrimeric G proteins. Cell Signal, 23 (3): 550-4. [PMID:21070854]
7. Li B, Zhong L, Yang X, Andersson T, Huang M, Tang SJ. (2011) WNT5A signaling contributes to Aβ-induced neuroinflammation and neurotoxicity. PLoS ONE, 6 (8): e22920. [PMID:21857966]
8. Lu J, Zhang S, Nakano H, Simmons DG, Wang S, Kong S, Wang Q, Shen L, Tu Z, Wang W et al.. (2013) A positive feedback loop involving Gcm1 and Fzd5 directs chorionic branching morphogenesis in the placenta. PLoS Biol, 11 (4): e1001536. [PMID:23610556]
9. Sahores M, Gibb A, Salinas PC. (2010) Frizzled-5, a receptor for the synaptic organizer Wnt7a, regulates activity-mediated synaptogenesis. Development, 137 (13): 2215-25. [PMID:20530549]
10. Saitoh T, Hirai M, Katoh M. (2001) Molecular cloning and characterization of human Frizzled-5 gene on chromosome 2q33.3-q34 region. Int J Oncol, 19 (1): 105-10. [PMID:11408929]
11. Sen M, Lauterbach K, El-Gabalawy H, Firestein GS, Corr M, Carson DA. (2000) Expression and function of wingless and frizzled homologs in rheumatoid arthritis. Proc Natl Acad Sci USA, 97 (6): 2791-6. [PMID:10688908]
12. Steinhart Z, Pavlovic Z, Chandrashekhar M, Hart T, Wang X, Zhang X, Robitaille M, Brown KR, Jaksani S, Overmeer R et al.. (2017) Genome-wide CRISPR screens reveal a Wnt-FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors. Nat Med, 23 (1): 60-68. [PMID:27869803]
13. Tauriello DV, Jordens I, Kirchner K, Slootstra JW, Kruitwagen T, Bouwman BA, Noutsou M, Rüdiger SG, Schwamborn K, Schambony A et al.. (2012) Wnt/β-catenin signaling requires interaction of the Dishevelled DEP domain and C terminus with a discontinuous motif in Frizzled. Proc Natl Acad Sci USA, 109 (14): E812-20. [PMID:22411803]
14. Ueno K, Hirata H, Hinoda Y, Dahiya R. (2013) Frizzled homolog proteins, microRNAs and Wnt signaling in cancer. Int J Cancer, 132 (8): 1731-40. [PMID:22833265]
15. van Es JH, Jay P, Gregorieff A, van Gijn ME, Jonkheer S, Hatzis P, Thiele A, van den Born M, Begthel H, Brabletz T et al.. (2005) Wnt signalling induces maturation of Paneth cells in intestinal crypts. Nat Cell Biol, 7 (4): 381-6. [PMID:15778706]
16. Wright SC, Cañizal MCA, Benkel T, Simon K, Le Gouill C, Matricon P, Namkung Y, Lukasheva V, König GM, Laporte SA et al.. (2018) FZD5 is a Gαq-coupled receptor that exhibits the functional hallmarks of prototypical GPCRs. Sci Signal, 11 (559). [PMID:30514810]
17. Zerlin M, Julius MA, Kitajewski J. (2008) Wnt/Frizzled signaling in angiogenesis. Angiogenesis, 11 (1): 63-9. [PMID:18253847]
