calpain 1 | C2: Calpain | IUPHAR/BPS Guide to PHARMACOLOGY

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calpain 1

Target not currently curated in GtoImmuPdb

Target id: 2336

Nomenclature: calpain 1

Family: C2: Calpain

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 714 11q13 CAPN1 calpain 1
Mouse - 713 19 A Capn1 calpain 1
Rat - 713 1q43 Capn1 calpain 1
Previous and Unofficial Names
calcium-activated neutral proteinase 1 | calpain mu-type | calpain-1 catalytic subunit | CANP | CANP 1 | Capa1 | micromolar-calpain | mu-calpain | muCANP | calpain 1, (mu/I) large subunit
Database Links
Specialist databases
MEROPS C02.001 (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number:

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 4b [PMID: 20690647] Pig Inhibition 7.6 pKi 2
pKi 7.6 (Ki 2.3x10-8 M) [2]
mercaptoacrylate inhibitor of calpain 1 Pig Inhibition 8.2 pIC50 1
pIC50 8.2 (IC50 6x10-9 M) [1]


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1. Adams SE, Parr C, Miller DJ, Allemann RK, Hallett MB. (2012) Potent inhibition of Ca2+-dependent activation of calpain-1 by novel mercaptoacrylates. Med.Chem.Commun., 3: 566.

2. Ovat A, Li ZZ, Hampton CY, Asress SA, Fernández FM, Glass JD, Powers JC. (2010) Peptidyl alpha-ketoamides with nucleobases, methylpiperazine, and dimethylaminoalkyl substituents as calpain inhibitors. J. Med. Chem., 53 (17): 6326-36. [PMID:20690647]

How to cite this page

C2: Calpain: calpain 1. Last modified on 29/01/2016. Accessed on 22/01/2020. IUPHAR/BPS Guide to PHARMACOLOGY,