Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	714	11q13	CAPN1	calpain 1
Mouse	-	713	19 A	Capn1	calpain 1
Rat	-	713	1q43	Capn1	calpain 1

Previous and Unofficial Names

calcium-activated neutral proteinase 1 | calpain mu-type | calpain-1 catalytic subunit | CANP | CANP 1 | Capa1 | micromolar-calpain | mu-calpain | muCANP | calpain 1, (mu/I) large subunit

Database Links
Specialist databases
MEROPS	C02.001 (Hs)
Other databases
BRENDA	3.4.22.52
ChEMBL Target	CHEMBL3891 (Hs), CHEMBL3747 (Rn)
Ensembl Gene	ENSG00000014216 (Hs), ENSMUSG00000024942 (Mm), ENSRNOG00000020935 (Rn)
Entrez Gene	823 (Hs), 12333 (Mm), 29153 (Rn)
Human Protein Atlas	ENSG00000014216 (Hs)
KEGG Enzyme	3.4.22.52
KEGG Gene	hsa:823 (Hs), mmu:12333 (Mm), rno:29153 (Rn)
OMIM	114220 (Hs)
RefSeq Nucleotide	NM_001198868 (Hs), NM_001198869 (Hs), NM_005186 (Hs), NM_001110504 (Mm), NM_007600 (Mm), NM_019152 (Rn)
RefSeq Protein	NP_001185798 (Hs), NP_005177 (Hs), NP_001185797 (Hs), NP_031626 (Mm), NP_001103974 (Mm), NP_062025 (Rn)
UniProtKB	P07384 (Hs), O35350 (Mm), P97571 (Rn)
Wikipedia	CAPN1 (Hs)

Enzyme Reaction
EC Number: 3.4.22.52

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference compound 4b [PMID: 20690647] Pig Inhibition 7.6 pKi 2 ⤷ pKi 7.6 (Ki 2.3x10-8 M) [2] mercaptoacrylate inhibitor of calpain 1 Pig Inhibition 8.2 pIC50 1 ⤷ pIC50 8.2 (IC50 6x10-9 M) [1]