cathepsin D | A1: Pepsin | IUPHAR/BPS Guide to PHARMACOLOGY

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cathepsin D

Target not currently curated in GtoImmuPdb

Target id: 2345

Nomenclature: cathepsin D

Family: A1: Pepsin

Annotation status:  image of an orange circle Annotated and awaiting review. Please contact us if you can help with reviewing.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 412 11p15.5 CTSD cathepsin D
Mouse - 410 7 F5 Ctsd cathepsin D
Rat - 407 1q41 Ctsd cathepsin D
Previous and Unofficial Names
CatD | CD | ceroid-lipofuscinosis, neuronal 10 | CLN10 | CPSD
Database Links
Specialist databases
MEROPS A01.009 (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number:

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 3 [PMID: 8410973] Hs Inhibition 7.7 pKi 3
pKi 7.7 (Ki 1.8x10-8 M) [3]
compound 1 [PMID: 10498202] Hs Inhibition 9.2 pIC50 1
pIC50 9.2 (IC50 7x10-10 M) [1]
grassystatin A Hs Inhibition 7.6 pIC50 2
pIC50 7.6 (IC50 2.65x10-8 M) [2]
Clinically-Relevant Mutations and Pathophysiology
Disease:  Ceroid lipofuscinosis, neuronal, 10
Synonyms: Cathepsin D deficiency
CLN10 disease [Orphanet: ORPHA228337]
Neuronal ceroid lipofuscinosis [Disease Ontology: DOID:14503]
Disease Ontology: DOID:14503
OMIM: 610127
Orphanet: ORPHA228337


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1. Dumas J, Brittelli D, Chen J, Dixon B, Hatoum-Mokdad H, König G, Sibley R, Witowsky J, Wong S. (1999) Synthesis and structure activity relationships of novel small molecule cathepsin D inhibitors. Bioorg. Med. Chem. Lett., 9 (17): 2531-6. [PMID:10498202]

2. Kwan JC, Eksioglu EA, Liu C, Paul VJ, Luesch H. (2009) Grassystatins A-C from marine cyanobacteria, potent cathepsin E inhibitors that reduce antigen presentation. J. Med. Chem., 52 (18): 5732-47. [PMID:19715320]

3. Rao CM, Scarborough PE, Kay J, Batley B, Rapundalo S, Klutchko S, Taylor MD, Lunney EA, Humblet CC, Dunn BM. (1993) Specificity in the binding of inhibitors to the active site of human/primate aspartic proteinases: analysis of P2-P1-P1'-P2' variation. J. Med. Chem., 36 (18): 2614-20. [PMID:8410973]

How to cite this page

A1: Pepsin: cathepsin D. Last modified on 29/07/2015. Accessed on 17/02/2020. IUPHAR/BPS Guide to PHARMACOLOGY,