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proprotein convertase subtilisin/kexin type 2

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Target not currently curated in GtoImmuPdb

Target id: 2383

Nomenclature: proprotein convertase subtilisin/kexin type 2

Family: S8: Subtilisin

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 638 20p12.1 PCSK2 proprotein convertase subtilisin/kexin type 2
Mouse - 637 2 70.89 cM Pcsk2 proprotein convertase subtilisin/kexin type 2
Rat - 637 3q41 Pcsk2 proprotein convertase subtilisin/kexin type 2
Previous and Unofficial Names Click here for help
NEC 2 | PC2 | Phpp-2 | prohormone convertase 2 | proprotein convertase 2 | SPC2 | neuroendocrine convertase 2
Database Links Click here for help
Specialist databases
MEROPS S08.073 (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction Click here for help
EC Number:

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Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
peptide 18 [PMID: 24350995] Small molecule or natural product Click here for species-specific activity table Hs Inhibition 9.6 pKi 1
pKi 9.6 (Ki 2.4x10-10 M) [1]


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1. Kwiatkowska A, Couture F, Levesque C, Ly K, Desjardins R, Beauchemin S, Prahl A, Lammek B, Neugebauer W, Dory YL et al.. (2014) Design, synthesis, and structure-activity relationship studies of a potent PACE4 inhibitor. J Med Chem, 57 (1): 98-109. [PMID:24350995]

How to cite this page

S8: Subtilisin: proprotein convertase subtilisin/kexin type 2. Last modified on 27/07/2015. Accessed on 16/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY,