Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	638	20p12.1	PCSK2	proprotein convertase subtilisin/kexin type 2
Mouse	-	637	2 70.89 cM	Pcsk2	proprotein convertase subtilisin/kexin type 2
Rat	-	637	3q41	Pcsk2	proprotein convertase subtilisin/kexin type 2

Previous and Unofficial Names

NEC 2 | PC2 | Phpp-2 | prohormone convertase 2 | proprotein convertase 2 | SPC2 | neuroendocrine convertase 2

Database Links
Specialist databases
MEROPS	S08.073 (Hs)
Other databases
Alphafold	P16519 (Hs), P21661 (Mm), P28841 (Rn)
BRENDA	3.4.21.94
CATH/Gene3D	2.60.120.260, 3.40.50.200
ChEMBL Target	CHEMBL2433 (Hs)
Ensembl Gene	ENSG00000125851 (Hs), ENSMUSG00000027419 (Mm), ENSRNOG00000005438 (Rn)
Entrez Gene	5126 (Hs), 18549 (Mm), 25121 (Rn)
Human Protein Atlas	ENSG00000125851 (Hs)
KEGG Enzyme	3.4.21.94
KEGG Gene	hsa:5126 (Hs), mmu:18549 (Mm), rno:25121 (Rn)
OMIM	162151 (Hs)
Pharos	P16519 (Hs)
RefSeq Nucleotide	NM_001201529 (Hs), NM_002594 (Hs), NM_001201528 (Hs), NM_008792 (Mm), NM_012746 (Rn)
RefSeq Protein	NP_002585 (Hs), NP_001188458 (Hs), NP_001188457 (Hs), NP_032818 (Mm), NP_036878 (Rn)
UniProtKB	P16519 (Hs), P21661 (Mm), P28841 (Rn)
Wikipedia	PCSK2 (Hs)

Enzyme Reaction
EC Number: 3.4.21.94

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference peptide 18 [PMID: 24350995] Hs Inhibition 9.6 pKi 1 ⤷ pKi 9.6 (Ki 2.4x10-10 M) [1]