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pepsinogen A5

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Target not currently curated in GtoImmuPdb

Target id: 2390

Nomenclature: pepsinogen A5

Family: A1: Pepsin

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 388 11q12.2 PGA5 pepsinogen A5
Previous and Unofficial Names Click here for help
Pepsin A-5 | pepsinogen 5, group I (pepsinogen A)
Database Links Click here for help
Specialist databases
MEROPS A01.071 (Hs)
Other databases
Alphafold P0DJD9 (Hs)
BRENDA 3.4.23.1
CATH/Gene3D 2.40.70.10
ChEMBL Target CHEMBL3295 (Hs)
Ensembl Gene ENSG00000256713 (Hs)
Entrez Gene 5222 (Hs)
Human Protein Atlas ENSG00000256713 (Hs)
KEGG Enzyme 3.4.23.1
KEGG Gene hsa:5222 (Hs)
OMIM 169730 (Hs)
Pharos P0DJD9 (Hs)
RefSeq Nucleotide NM_014224 (Hs)
RefSeq Protein NP_055039 (Hs)
UniProtKB P0DJD9 (Hs)
Wikipedia PGA5 (Hs)
Enzyme Reaction Click here for help
EC Number: 3.4.23.1

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 3 [PMID: 8410973] Small molecule or natural product Click here for species-specific activity table Hs Inhibition 8.0 pKi 2
⤷ pKi 8.0 (Ki 1.1x10-8 M) [2]
Inhibitor Comments
The approved drug sucralfate can inhibit pepsin enzymatic activity [1].

References

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1. Furukawa O, Matsui H, Suzuki N. (1997) Effects of sucralfate and its components on acid- and pepsin-induced damage to rat gastric epithelial cells. Jpn J Pharmacol, 75 (1): 21-5. [PMID:9334882]

2. Rao CM, Scarborough PE, Kay J, Batley B, Rapundalo S, Klutchko S, Taylor MD, Lunney EA, Humblet CC, Dunn BM. (1993) Specificity in the binding of inhibitors to the active site of human/primate aspartic proteinases: analysis of P2-P1-P1'-P2' variation. J Med Chem, 36 (18): 2614-20. [PMID:8410973]

How to cite this page

A1: Pepsin: pepsinogen A5. Last modified on 12/09/2019. Accessed on 05/10/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2390.