pepsinogen A5 | A1: Pepsin | IUPHAR/BPS Guide to PHARMACOLOGY

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pepsinogen A5

Target not currently curated in GtoImmuPdb

Target id: 2390

Nomenclature: pepsinogen A5

Family: A1: Pepsin

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 388 11q13 PGA5 pepsinogen A5
Previous and Unofficial Names
Pepsin A-5 | pepsinogen 5, group I (pepsinogen A)
Database Links
Specialist databases
MEROPS A01.071 (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number:

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 3 [PMID: 8410973] Hs Inhibition 8.0 pKi 2
pKi 8.0 (Ki 1.1x10-8 M) [2]
Inhibitor Comments
The approved drug sucralfate can inhibit pepsin enzymatic activity [1].


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1. Furukawa O, Matsui H, Suzuki N. (1997) Effects of sucralfate and its components on acid- and pepsin-induced damage to rat gastric epithelial cells. Jpn. J. Pharmacol., 75 (1): 21-5. [PMID:9334882]

2. Rao CM, Scarborough PE, Kay J, Batley B, Rapundalo S, Klutchko S, Taylor MD, Lunney EA, Humblet CC, Dunn BM. (1993) Specificity in the binding of inhibitors to the active site of human/primate aspartic proteinases: analysis of P2-P1-P1'-P2' variation. J. Med. Chem., 36 (18): 2614-20. [PMID:8410973]

How to cite this page

A1: Pepsin: pepsinogen A5. Last modified on 12/09/2019. Accessed on 02/07/2020. IUPHAR/BPS Guide to PHARMACOLOGY,