Top ▲

Ras converting CAAX endopeptidase 1

Click here for help

Target not currently curated in GtoImmuPdb

Target id: 2412

Nomenclature: Ras converting CAAX endopeptidase 1

Family: M79: Prenyl protease 2

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 329 11q13.2 RCE1 Ras converting CAAX endopeptidase 1
Mouse 7 329 19 A Rce1 Ras converting CAAX endopeptidase 1
Rat 6 308 1q43 Rce1 Ras converting CAAX endopeptidase 1
Previous and Unofficial Names Click here for help
RCE1A | RCE1B | CAAX prenyl protease 2 | FACE2 | prenyl protein-specific endoprotease 2 | Ras and a-factor-converting enzyme 1 homolog | farnesylated protein-converting enzyme 2 | RCE1 homolog, prenyl protein protease (S. cerevisiae) | RCE1 homolog, prenyl protein peptidase (S. cerevisiae)
Database Links Click here for help
Specialist databases
MEROPS M79.002 (Hs)
Other databases
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 3.4.22.-

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
CID16197121 Small molecule or natural product Primary target of this compound Hs Inhibition 6.7 pIC50 1
pIC50 6.7 (IC50 1.86x10-7 M) Activity reported as AU50 [1]
compound 3 [PMID: 17942791] Small molecule or natural product Primary target of this compound Hs Inhibition 5.1 pIC50 2
pIC50 5.1 (IC50 9x10-6 M) [2]

References

Show »

1. Broad Institute. Human Ras-Converting Enzyme Inhibition Assay AID 588849. Accessed on 15/07/2015. Modified on 15/07/2015. PubChemBioAssay, https://pubchem.ncbi.nlm.nih.gov/assay/assay.cgi?aid=588849

2. Manandhar SP, Hildebrandt ER, Schmidt WK. (2007) Small-molecule inhibitors of the Rce1p CaaX protease. J Biomol Screen, 12 (7): 983-93. [PMID:17942791]

How to cite this page

M79: Prenyl protease 2: Ras converting CAAX endopeptidase 1. Last modified on 15/07/2015. Accessed on 07/05/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2412.