Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	7	329	11q13.2	RCE1	Ras converting CAAX endopeptidase 1
Mouse	7	329	19 A	Rce1	Ras converting CAAX endopeptidase 1
Rat	6	308	1q43	Rce1	Ras converting CAAX endopeptidase 1

Previous and Unofficial Names

CAAX prenyl protease 2 | FACE2 | prenyl protein-specific endoprotease 2 | Ras and a-factor-converting enzyme 1 homolog | RCE1A | RCE1B | farnesylated protein-converting enzyme 2 | RCE1 homolog, prenyl protein protease (S. cerevisiae) | RCE1 homolog, prenyl protein peptidase (S. cerevisiae)

Database Links
Specialist databases
MEROPS	M79.002 (Hs)
Other databases
Alphafold	Q9Y256 (Hs), P57791 (Mm), B0BMW8 (Rn)
BRENDA	3.4.22.-
ChEMBL Target	CHEMBL3411 (Hs), CHEMBL1075287 (Mm)
Ensembl Gene	ENSG00000173653 (Hs), ENSMUSG00000024889 (Mm), ENSRNOG00000019468 (Rn)
Entrez Gene	9986 (Hs), 19671 (Mm), 309153 (Rn)
Human Protein Atlas	ENSG00000173653 (Hs)
KEGG Enzyme	3.4.22.-
KEGG Gene	hsa:9986 (Hs), mmu:19671 (Mm), rno:309153 (Rn)
OMIM	605385 (Hs)
Pharos	Q9Y256 (Hs)
RefSeq Nucleotide	NM_005133 (Hs), NM_001032279 (Hs), NM_023131 (Mm), NM_001100585 (Rn)
RefSeq Protein	NP_001027450 (Hs), NP_005124 (Hs), NP_075620 (Mm), NP_001094055 (Rn)
UniProtKB	Q9Y256 (Hs), P57791 (Mm), B0BMW8 (Rn)
Wikipedia	RCE1 (Hs)

Enzyme Reaction
EC Number: 3.4.22.-

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference CID16197121 Hs Inhibition 6.7 pIC50 1 ⤷ pIC50 6.7 (IC50 1.86x10-7 M) Activity reported as AU50 [1] compound 3 [PMID: 17942791] Hs Inhibition 5.1 pIC50 2 ⤷ pIC50 5.1 (IC50 9x10-6 M) [2]