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SUMO specific peptidase 1

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Target not currently curated in GtoImmuPdb

Target id: 2414

Nomenclature: SUMO specific peptidase 1

Family: C48: Ulp1 endopeptidase

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 644 12q13.11 SENP1 SUMO specific peptidase 1
Mouse - 640 15 54.04 cM Senp1 SUMO1/sentrin specific peptidase 1
Rat - - 7q36 Senp1 SUMO specific peptidase 1
Previous and Unofficial Names Click here for help
Sentrin-specific protease 1 | SUMO1/sentrin specific peptidase 1
Database Links Click here for help
Specialist databases
MEROPS C48.002 (Hs)
Other databases
Alphafold Q9P0U3 (Hs), P59110 (Mm)
BRENDA 3.4.22.68
ChEMBL Target CHEMBL1909484 (Hs)
Ensembl Gene ENSG00000079387 (Hs), ENSMUSG00000033075 (Mm), ENSRNOG00000022260 (Rn)
Entrez Gene 29843 (Hs)
Human Protein Atlas ENSG00000079387 (Hs)
KEGG Enzyme 3.4.22.68
KEGG Gene hsa:29843 (Hs)
OMIM 612157 (Hs)
Pharos Q9P0U3 (Hs)
RefSeq Nucleotide NM_001267595 (Hs), NM_001267594 (Hs)
RefSeq Protein NP_001254524 (Hs), NP_001254523 (Hs)
UniProtKB Q9P0U3 (Hs), P59110 (Mm)
Wikipedia SENP1 (Hs)
Enzyme Reaction Click here for help
EC Number: 3.4.22.68

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 8e [PMID: 23044371] Small molecule or natural product Hs Inhibition 5.7 pIC50 1
⤷ pIC50 5.7 (IC50 1.856x10-6 M) [1]
Immuno Process Associations
Immuno Process:  Immune regulation
Immuno Process:  Immune system development

References

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1. Chen Y, Wen D, Huang Z, Huang M, Luo Y, Liu B, Lu H, Wu Y, Peng Y, Zhang J. (2012) 2-(4-Chlorophenyl)-2-oxoethyl 4-benzamidobenzoate derivatives, a novel class of SENP1 inhibitors: Virtual screening, synthesis and biological evaluation. Bioorg Med Chem Lett, 22 (22): 6867-70. [PMID:23044371]

How to cite this page

C48: Ulp1 endopeptidase: SUMO specific peptidase 1. Last modified on 27/02/2018. Accessed on 09/09/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2414.