SUMO specific peptidase 1 | C48: Ulp1 endopeptidase | IUPHAR/BPS Guide to PHARMACOLOGY

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SUMO specific peptidase 1

Target not currently curated in GtoImmuPdb

Target id: 2414

Nomenclature: SUMO specific peptidase 1

Family: C48: Ulp1 endopeptidase

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 644 12q13.1 SENP1 SUMO specific peptidase 1
Mouse - 640 15 54.04 cM Senp1 SUMO1/sentrin specific peptidase 1
Rat - - 7q36 Senp1 SUMO specific peptidase 1
Previous and Unofficial Names
Sentrin-specific protease 1 | SUMO1/sentrin specific peptidase 1
Database Links
Specialist databases
MEROPS C48.002 (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number:

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 8e [PMID: 23044371] Hs Inhibition 5.7 pIC50 1
pIC50 5.7 (IC50 1.856x10-6 M) [1]


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1. Chen Y, Wen D, Huang Z, Huang M, Luo Y, Liu B, Lu H, Wu Y, Peng Y, Zhang J. (2012) 2-(4-Chlorophenyl)-2-oxoethyl 4-benzamidobenzoate derivatives, a novel class of SENP1 inhibitors: Virtual screening, synthesis and biological evaluation. Bioorg. Med. Chem. Lett., 22 (22): 6867-70. [PMID:23044371]

How to cite this page

C48: Ulp1 endopeptidase: SUMO specific peptidase 1. Last modified on 27/02/2018. Accessed on 29/01/2020. IUPHAR/BPS Guide to PHARMACOLOGY,