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SUMO specific peptidase 1

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Target not currently curated in GtoImmuPdb

Target id: 2414

Nomenclature: SUMO specific peptidase 1

Family: C48: Ulp1 endopeptidase

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 644 12q13.11 SENP1 SUMO specific peptidase 1
Mouse - 640 15 54.04 cM Senp1 SUMO1/sentrin specific peptidase 1
Rat - - 7q36 Senp1 SUMO specific peptidase 1
Previous and Unofficial Names Click here for help
Sentrin-specific protease 1 | SUMO1/sentrin specific peptidase 1
Database Links Click here for help
Specialist databases
MEROPS C48.002 (Hs)
Other databases
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 3.4.22.68

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 8e [PMID: 23044371] Small molecule or natural product Hs Inhibition 5.7 pIC50 1
pIC50 5.7 (IC50 1.856x10-6 M) [1]
Immuno Process Associations
Immuno Process:  Immune regulation
GO Annotations:  Associated to 1 GO processes, IEA only
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GO:0010724 regulation of definitive erythrocyte differentiation IEA
Immuno Process:  Immune system development
GO Annotations:  Associated to 1 GO processes, IEA only
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GO:0010724 regulation of definitive erythrocyte differentiation IEA

References

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1. Chen Y, Wen D, Huang Z, Huang M, Luo Y, Liu B, Lu H, Wu Y, Peng Y, Zhang J. (2012) 2-(4-Chlorophenyl)-2-oxoethyl 4-benzamidobenzoate derivatives, a novel class of SENP1 inhibitors: Virtual screening, synthesis and biological evaluation. Bioorg. Med. Chem. Lett., 22 (22): 6867-70. [PMID:23044371]

How to cite this page

C48: Ulp1 endopeptidase: SUMO specific peptidase 1. Last modified on 27/02/2018. Accessed on 24/01/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2414.