tripeptidyl peptidase 2 | S8: Subtilisin | IUPHAR/BPS Guide to PHARMACOLOGY

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tripeptidyl peptidase 2

Target not currently curated in GtoImmuPdb

Target id: 2423

Nomenclature: tripeptidyl peptidase 2

Family: S8: Subtilisin

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1249 13q32-q33 TPP2 tripeptidyl peptidase 2
Mouse - 1262 1 C1.1 Tpp2 tripeptidyl peptidase II
Rat - 1249 9q22 Tpp2 tripeptidyl peptidase 2
Previous and Unofficial Names
TppII | tripeptidyl aminopeptidase
Database Links
Specialist databases
MEROPS S08.090 (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number:

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
example 8 [WO1999033801A1] Hs Inhibition 9.4 pKi 1
pKi 9.4 (Ki 3.6x10-10 M) [1]
peptide 4 [PMID: 18294843] Hs Inhibition 7.7 pKi 2
pKi 7.7 (Ki 2x10-8 M) [2]


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1. Chen Y, Ganellin CR, Rose C, Samad S, Schwartz J-C, Vargas F, Zhao L. (1999) Tripeptidyl peptidase inhibitors. Patent number: WO1999033801 A1. Assignee: Inst Nat Sante Rech Med, Chen Y, Ganellin CR, Rose C, Samad S, Schwartz J-C, Vargas F, Zhao L. Priority date: 23/12/1998. Publication date: 08/07/1999.

2. Levengood MR, van der Donk WA. (2008) Use of lantibiotic synthetases for the preparation of bioactive constrained peptides. Bioorg. Med. Chem. Lett., 18 (10): 3025-8. [PMID:18294843]

How to cite this page

S8: Subtilisin: tripeptidyl peptidase 2. Last modified on 16/07/2015. Accessed on 18/09/2019. IUPHAR/BPS Guide to PHARMACOLOGY,