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ubiquitin C-terminal hydrolase L1

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Target not currently curated in GtoImmuPdb

Target id: 2426

Nomenclature: ubiquitin C-terminal hydrolase L1

Family: C12: Ubiquitin C-terminal hydrolase

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 223 4p13 UCHL1 ubiquitin C-terminal hydrolase L1
Mouse - 223 5 35.95 cM Uchl1 ubiquitin carboxy-terminal hydrolase L1
Rat - 223 14p11 Uchl1 ubiquitin C-terminal hydrolase L1
Previous and Unofficial Names Click here for help
gad | gracile axonal dystrophy | PARK5 | ubiquitin thioesterase L1 | ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
Database Links Click here for help
Specialist databases
MEROPS C12.001 (Hs)
Other databases
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Orphanet
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 3.4.19.12

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
LDN-91946 Small molecule or natural product Primary target of this compound Hs Inhibition 5.6 pKi 1
pKi 5.6 (Ki 2.3x10-6 M) [1]
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Neurodegeneration with optic atrophy, childhood onset
Synonyms: Early-onset progressive neurodegeneration - blindness - ataxia - spasticity [Orphanet: ORPHA352654]
OMIM: 615491
Orphanet: ORPHA352654
Disease:  Parkinson disease 5, autosomal dominant; PARK5
Synonyms: Parkinson's disease [Disease Ontology: DOID:14330]
Disease Ontology: DOID:14330
OMIM: 613643
Disease:  Young adult-onset Parkinsonism
Orphanet: ORPHA2828

References

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1. Mermerian AH, Case A, Stein RL, Cuny GD. (2007) Structure-activity relationship, kinetic mechanism, and selectivity for a new class of ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitors. Bioorg. Med. Chem. Lett., 17 (13): 3729-32. [PMID:17449248]

How to cite this page

C12: Ubiquitin C-terminal hydrolase: ubiquitin C-terminal hydrolase L1. Last modified on 29/01/2016. Accessed on 28/11/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2426.