ubiquitin C-terminal hydrolase L3 | C12: Ubiquitin C-terminal hydrolase | IUPHAR/BPS Guide to PHARMACOLOGY

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ubiquitin C-terminal hydrolase L3

Target not currently curated in GtoImmuPdb

Target id: 2427

Nomenclature: ubiquitin C-terminal hydrolase L3

Family: C12: Ubiquitin C-terminal hydrolase

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 230 13q21.33 UCHL3 ubiquitin C-terminal hydrolase L3
Mouse - 230 14 E2.3 Uchl3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
Rat - 230 15q21 Uchl3 ubiquitin C-terminal hydrolase L3
Previous and Unofficial Names
ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
Database Links
Specialist databases
MEROPS C12.003 (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number:

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 6 [PMID: 17948018] Hs Inhibition 6.2 pIC50 1
pIC50 6.2 (IC50 6x10-7 M) [1]


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1. Love KR, Catic A, Schlieker C, Ploegh HL. (2007) Mechanisms, biology and inhibitors of deubiquitinating enzymes. Nat. Chem. Biol., 3 (11): 697-705. [PMID:17948018]

How to cite this page

C12: Ubiquitin C-terminal hydrolase: ubiquitin C-terminal hydrolase L3. Last modified on 29/01/2016. Accessed on 18/10/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2427.