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ubiquitin C-terminal hydrolase L3

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Target not currently curated in GtoImmuPdb

Target id: 2427

Nomenclature: ubiquitin C-terminal hydrolase L3

Family: C12: Ubiquitin C-terminal hydrolase

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 230 13q22.2 UCHL3 ubiquitin C-terminal hydrolase L3
Mouse - 230 14 50.9 cM Uchl3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
Rat - 230 15q21 Uchl3 ubiquitin C-terminal hydrolase L3
Previous and Unofficial Names Click here for help
ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
Database Links Click here for help
Specialist databases
MEROPS C12.003 (Hs)
Other databases
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 3.4.19.12

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 6 [PMID: 17948018] Small molecule or natural product Primary target of this compound Hs Inhibition 6.2 pIC50 1
pIC50 6.2 (IC50 6x10-7 M) [1]
Immuno Process Associations
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 1 GO processes
GO:0016567 protein ubiquitination TAS

References

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1. Love KR, Catic A, Schlieker C, Ploegh HL. (2007) Mechanisms, biology and inhibitors of deubiquitinating enzymes. Nat. Chem. Biol., 3 (11): 697-705. [PMID:17948018]

How to cite this page

C12: Ubiquitin C-terminal hydrolase: ubiquitin C-terminal hydrolase L3. Last modified on 29/01/2016. Accessed on 28/11/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2427.