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ubiquitin C-terminal hydrolase L3

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Target not currently curated in GtoImmuPdb

Target id: 2427

Nomenclature: ubiquitin C-terminal hydrolase L3

Family: C12: Ubiquitin C-terminal hydrolase

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 230 13q22.2 UCHL3 ubiquitin C-terminal hydrolase L3
Mouse - 230 14 50.9 cM Uchl3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
Rat - 230 15q21 Uchl3 ubiquitin C-terminal hydrolase L3
Previous and Unofficial Names Click here for help
ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
Database Links Click here for help
Specialist databases
MEROPS C12.003 (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction Click here for help
EC Number:

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Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 6 [PMID: 17948018] Small molecule or natural product Primary target of this compound Hs Inhibition 6.2 pIC50 1
pIC50 6.2 (IC50 6x10-7 M) [1]
Immuno Process Associations
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 1 GO processes
GO:0016567 protein ubiquitination TAS


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1. Love KR, Catic A, Schlieker C, Ploegh HL. (2007) Mechanisms, biology and inhibitors of deubiquitinating enzymes. Nat Chem Biol, 3 (11): 697-705. [PMID:17948018]

How to cite this page

C12: Ubiquitin C-terminal hydrolase: ubiquitin C-terminal hydrolase L3. Last modified on 29/01/2016. Accessed on 20/05/2022. IUPHAR/BPS Guide to PHARMACOLOGY,