Top ▲
Target not currently curated in GtoImmuPdb
Target id: 2464
Nomenclature: 4-aminobutyrate aminotransferase
Abbreviated Name: GABA-T
Family: GABA turnover
Gene and Protein Information | ||||||
Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | - | 500 | 16p13.2 | ABAT | 4-aminobutyrate aminotransferase | |
Mouse | - | 500 | 16 A1 | Abat | 4-aminobutyrate aminotransferase | |
Rat | - | 500 | 10q12 | Abat | 4-aminobutyrate aminotransferase |
Previous and Unofficial Names |
GABA aminotransferase | GABA transaminase | GABA-AT | GABA-T | Gamma-amino-N-butyrate transaminase | L-AIBAT |
Database Links | |
Alphafold | P80404 (Hs), P61922 (Mm), P50554 (Rn) |
BRENDA | 2.6.1.19, 2.6.1.22 |
CATH/Gene3D | 3.90.1150.10, 3.40.640.10 |
ChEMBL Target | CHEMBL2044 (Hs), CHEMBL4523258 (Mm), CHEMBL3148 (Rn) |
DrugBank Target | P80404 (Hs) |
Ensembl Gene | ENSG00000183044 (Hs), ENSMUSG00000057880 (Mm), ENSRNOG00000002636 (Rn) |
Entrez Gene | 18 (Hs), 268860 (Mm), 81632 (Rn) |
Human Protein Atlas | ENSG00000183044 (Hs) |
KEGG Enzyme | 2.6.1.19, 2.6.1.22 |
KEGG Gene | hsa:18 (Hs), mmu:268860 (Mm), rno:81632 (Rn) |
OMIM | 137150 (Hs) |
Orphanet | ORPHA117617 (Hs) |
Pharos | P80404 (Hs) |
RefSeq Nucleotide | NM_001127448 (Hs), NM_000663 (Hs), NM_020686 (Hs), NM_172961 (Mm), NM_001170978 (Mm), NM_031003 (Rn) |
RefSeq Protein | NP_000654 (Hs), NP_065737 (Hs), NP_001120920 (Hs), NP_001164449 (Mm), NP_766549 (Mm), NP_112265 (Rn) |
UniProtKB | P80404 (Hs), P61922 (Mm), P50554 (Rn) |
Wikipedia | ABAT (Hs) |
Enzyme Reaction | ||||||||
|
Cofactors | ||||||||
|
Download all structure-activity data for this target as a CSV file
Inhibitors | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
Clinically-Relevant Mutations and Pathophysiology | ||||||||||||||||
|
1. Lippert B, Metcalf BW, Jung MJ, Casara P. (1977) 4-amino-hex-5-enoic acid, a selective catalytic inhibitor of 4-aminobutyric-acid aminotransferase in mammalian brain. Eur J Biochem, 74 (3): 441-5. [PMID:856582]
2. Medina-Kauwe LK, Nyhan WL, Gibson KM, Tobin AJ. (1998) Identification of a familial mutation associated with GABA-transaminase deficiency disease. Neurobiol Dis, 5 (2): 89-96. [PMID:9746906]
3. Silverman RB. (2012) The 2011 E. B. Hershberg award for important discoveries in medicinally active substances: (1S,3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid (CPP-115), a GABA aminotransferase inactivator and new treatment for drug addiction and infantile spasms. J Med Chem, 55 (2): 567-75. [PMID:22168767]
4. Tao YH, Yuan Z, Tang XQ, Xu HB, Yang XL. (2006) Inhibition of GABA shunt enzymes' activity by 4-hydroxybenzaldehyde derivatives. Bioorg Med Chem Lett, 16 (3): 592-5. [PMID:16290145]
GABA turnover: 4-aminobutyrate aminotransferase. Last modified on 23/09/2015. Accessed on 08/12/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2464.