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aldehyde dehydrogenase 5 family member A1

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Target not currently curated in GtoImmuPdb

Target id: 2466

Nomenclature: aldehyde dehydrogenase 5 family member A1

Abbreviated Name: SSADH

Family: GABA turnover

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 535 6p22.3 ALDH5A1 aldehyde dehydrogenase 5 family member A1
Mouse - 523 13 10.77 cM Aldh5a1 aldhehyde dehydrogenase family 5, subfamily A1
Rat - 523 17p11 Aldh5a1 aldehyde dehydrogenase 5 family, member A1
Previous and Unofficial Names Click here for help
NAD(+)-dependent succinic semialdehyde dehydrogenase | SSADH, SSDH | succinate-semialdehyde dehydrogenase, mitochondrial | aldehyde dehydrogenase 5 family, member A1 | aldehyde dehydrogenase 5 family | aldhehyde dehydrogenase family 5, subfamily A1 | aldhehyde dehydrogenase family 5
Database Links Click here for help
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction Click here for help
EC Number: 4-Oxobutanoate + NAD + H2O = succinic acid + NADH + 2H+
4-hydroxy-trans-2-nonenal + NAD + H2O = 4-hydroxy-trans-2-nonenoate + NADH + 2H+
Cofactors Click here for help
Cofactor Species Comments Reference
NAD None

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Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
4-acryloylphenol Small molecule or natural product Primary target of this compound Click here for species-specific activity table Hs Inhibition 6.5 pIC50 1
pIC50 6.5 (IC50 3.5x10-7 M) [1]
Inhibitor Comments
This enzyme is inhibited by the approved drug valproic acid.
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Succinic semialdehyde dehydrogenase deficiency; SSADHD
Synonyms: 4-hydroxybutyric aciduria [Orphanet: ORPHA22]
Disease Ontology: DOID:0060175
OMIM: 271980
Orphanet: ORPHA22


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1. Tao YH, Yuan Z, Tang XQ, Xu HB, Yang XL. (2006) Inhibition of GABA shunt enzymes' activity by 4-hydroxybenzaldehyde derivatives. Bioorg Med Chem Lett, 16 (3): 592-5. [PMID:16290145]

How to cite this page

GABA turnover: aldehyde dehydrogenase 5 family member A1. Last modified on 29/01/2016. Accessed on 09/12/2023. IUPHAR/BPS Guide to PHARMACOLOGY,