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serine palmitoyltransferase long chain base subunit 1

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Target not currently curated in GtoImmuPdb

Target id: 2509

Nomenclature: serine palmitoyltransferase long chain base subunit 1

Abbreviated Name: SPT1

Family: Serine palmitoyltransferase

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 473 9q22.31 SPTLC1 serine palmitoyltransferase long chain base subunit 1
Mouse 1 473 13 B1 Sptlc1 serine palmitoyltransferase, long chain base subunit 1
Rat 1 473 17p14 Sptlc1 serine palmitoyltransferase, long chain base subunit 1
Previous and Unofficial Names Click here for help
hereditary sensory neuropathy, type 1 | HSN1 | LCB1 | Serine-palmitoyl-CoA transferase 1 | SPTI | serine palmitoyltransferase, long chain base subunit 1 | serine palmitoyltransferase
Database Links Click here for help
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 2.3.1.50 L-serine + palmitoyl-CoA -> 3-ketosphinganine + coenzyme A + CO2
Cofactors Click here for help
Cofactor Species Comments Reference
pyridoxal 5-phosphate Human

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
myriocin Small molecule or natural product Mm Inhibition 9.6 pKi 1
pKi 9.6 (Ki 2.8x10-10 M) [1]
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Neuropathy, hereditary sensory and autonomic, type IA; HSAN1A
Synonyms: Hereditary sensory and autonomic neuropathy [Disease Ontology: DOID:11533]
Hereditary sensory and autonomic neuropathy type 1 [Orphanet: ORPHA36386]
Disease Ontology: DOID:11533
OMIM: 162400
Orphanet: ORPHA36386

References

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1. Miyake Y, Kozutsumi Y, Nakamura S, Fujita T, Kawasaki T. (1995) Serine palmitoyltransferase is the primary target of a sphingosine-like immunosuppressant, ISP-1/myriocin. Biochem. Biophys. Res. Commun., 211 (2): 396-403. [PMID:7794249]

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