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sphingomyelin synthase 1

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Target not currently curated in GtoImmuPdb

Target id: 2520

Nomenclature: sphingomyelin synthase 1

Family: Sphingomyelin synthase

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 5 413 10q11.23 SGMS1 sphingomyelin synthase 1
Mouse 5 419 19 C1 Sgms1 sphingomyelin synthase 1
Rat 5 419 1q52 Sgms1 sphingomyelin synthase 1
Previous and Unofficial Names Click here for help
Phosphatidylcholine:ceramide cholinephosphotransferase 1 | Protein Mob | SMS1 | TMEM23 | transmembrane protein 23
Database Links Click here for help
Alphafold Q86VZ5 (Hs), Q8VCQ6 (Mm), Q7TSX5 (Rn)
BRENDA 2.7.8.27
ChEMBL Target CHEMBL3611965 (Hs), CHEMBL4523408 (Mm)
Ensembl Gene ENSG00000198964 (Hs), ENSMUSG00000040451 (Mm), ENSRNOG00000012536 (Rn)
Entrez Gene 259230 (Hs), 208449 (Mm), 353229 (Rn)
Human Protein Atlas ENSG00000198964 (Hs)
KEGG Enzyme 2.7.8.27
KEGG Gene hsa:259230 (Hs), mmu:208449 (Mm), rno:353229 (Rn)
OMIM 611573 (Hs)
Pharos Q86VZ5 (Hs)
RefSeq Nucleotide NM_147156 (Hs), NM_144792 (Mm), NM_001168526 (Mm), NM_001168525 (Mm), NM_181386 (Rn)
RefSeq Protein NP_671512 (Hs), NP_001161997 (Mm), NP_001161998 (Mm), NP_659041 (Mm), NP_852051 (Rn)
UniProtKB Q86VZ5 (Hs), Q8VCQ6 (Mm), Q7TSX5 (Rn)
Wikipedia SGMS1 (Hs)
Enzyme Reaction Click here for help
EC Number: 2.7.8.27 ceramide + phosphatidylcholine -> sphingomyelin + diacylglycerol

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 1j [PMID: 26314925] Small molecule or natural product Hs Inhibition 5.7 pIC50 1
⤷ pIC50 5.7 (IC50 2.1x10-6 M) [1]
sphingomyelin synthase 2 inhibitor 15w Small molecule or natural product Click here for species-specific activity table Immunopharmacology Ligand Hs Inhibition 4.3 pIC50 2
⤷ pIC50 4.3 (IC50 5.6x10-5 M) [2]
Description: Inhibition of purified human SMS1 in vitro.

References

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1. Li YL, Qi XY, Jiang H, Deng XD, Dong YP, Ding TB, Zhou L, Men P, Chu Y, Wang RX et al.. (2015) Discovery, synthesis and biological evaluation of 2-(4-(N-phenethylsulfamoyl)phenoxy)acetamides (SAPAs) as novel sphingomyelin synthase 1 inhibitors. Bioorg Med Chem, 23 (18): 6173-84. [PMID:26314925]

2. Mo M, Yang J, Jiang XC, Cao Y, Fei J, Chen Y, Qi X, Chu Y, Zhou L, Ye D. (2018) Discovery of 4-Benzyloxybenzo[ d]isoxazole-3-amine Derivatives as Highly Selective and Orally Efficacious Human Sphingomyelin Synthase 2 Inhibitors that Reduce Chronic Inflammation in db/ db Mice. J Med Chem, 61 (18): 8241-8254. [PMID:30074791]

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