sphingomyelin synthase 1 | Sphingomyelin synthase | IUPHAR/BPS Guide to PHARMACOLOGY

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sphingomyelin synthase 1

Target not currently curated in GtoImmuPdb

Target id: 2520

Nomenclature: sphingomyelin synthase 1

Family: Sphingomyelin synthase

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 419 10q11.2 SGMS1 sphingomyelin synthase 1
Mouse - 419 19 C1 Sgms1 sphingomyelin synthase 1
Rat - 419 1q52 Sgms1 sphingomyelin synthase 1
Previous and Unofficial Names
Phosphatidylcholine:ceramide cholinephosphotransferase 1 | Protein Mob | SMS1 | TMEM23 | transmembrane protein 23
Database Links
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 2.7.8.27 ceramide + phosphatidylcholine -> sphingomyelin + diacylglycerol

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 1j [PMID: 26314925] Hs Inhibition 5.7 pIC50 1
pIC50 5.7 (IC50 2.1x10-6 M) [1]
sphingomyelin synthase 2 inhibitor 15w Hs Inhibition 4.3 pIC50 2
pIC50 4.3 (IC50 5.6x10-5 M) [2]
Description: Inhibition of purified human SMS1 in vitro.
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 1 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0006954 inflammatory response IEA
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 1 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0071356 cellular response to tumor necrosis factor IEA

References

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1. Li YL, Qi XY, Jiang H, Deng XD, Dong YP, Ding TB, Zhou L, Men P, Chu Y, Wang RX et al.. (2015) Discovery, synthesis and biological evaluation of 2-(4-(N-phenethylsulfamoyl)phenoxy)acetamides (SAPAs) as novel sphingomyelin synthase 1 inhibitors. Bioorg. Med. Chem., 23 (18): 6173-84. [PMID:26314925]

2. Mo M, Yang J, Jiang XC, Cao Y, Fei J, Chen Y, Qi X, Chu Y, Zhou L, Ye D. (2018) Discovery of 4-Benzyloxybenzo[ d]isoxazole-3-amine Derivatives as Highly Selective and Orally Efficacious Human Sphingomyelin Synthase 2 Inhibitors that Reduce Chronic Inflammation in db/ db Mice. J. Med. Chem., 61 (18): 8241-8254. [PMID:30074791]

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