sphingomyelin synthase 1 | Sphingomyelin synthase | IUPHAR/BPS Guide to PHARMACOLOGY

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sphingomyelin synthase 1

Target not currently curated in GtoImmuPdb

Target id: 2520

Nomenclature: sphingomyelin synthase 1

Family: Sphingomyelin synthase

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 419 10q11.2 SGMS1 sphingomyelin synthase 1
Mouse - 419 19 C1 Sgms1 sphingomyelin synthase 1
Rat - 419 1q52 Sgms1 sphingomyelin synthase 1
Previous and Unofficial Names
Phosphatidylcholine:ceramide cholinephosphotransferase 1 | Protein Mob | SMS1 | TMEM23 | transmembrane protein 23
Database Links
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number: ceramide + phosphatidylcholine -> sphingomyelin + diacylglycerol

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Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 1j [PMID: 26314925] Hs Inhibition 5.7 pIC50 1
pIC50 5.7 (IC50 2.1x10-6 M) [1]
sphingomyelin synthase 2 inhibitor 15w Hs Inhibition 4.3 pIC50 2
pIC50 4.3 (IC50 5.6x10-5 M) [2]
Description: Inhibition of purified human SMS1 in vitro.
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 1 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0006954 inflammatory response IEA
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 1 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0071356 cellular response to tumor necrosis factor IEA


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1. Li YL, Qi XY, Jiang H, Deng XD, Dong YP, Ding TB, Zhou L, Men P, Chu Y, Wang RX et al.. (2015) Discovery, synthesis and biological evaluation of 2-(4-(N-phenethylsulfamoyl)phenoxy)acetamides (SAPAs) as novel sphingomyelin synthase 1 inhibitors. Bioorg. Med. Chem., 23 (18): 6173-84. [PMID:26314925]

2. Mo M, Yang J, Jiang XC, Cao Y, Fei J, Chen Y, Qi X, Chu Y, Zhou L, Ye D. (2018) Discovery of 4-Benzyloxybenzo[ d]isoxazole-3-amine Derivatives as Highly Selective and Orally Efficacious Human Sphingomyelin Synthase 2 Inhibitors that Reduce Chronic Inflammation in db/ db Mice. J. Med. Chem., 61 (18): 8241-8254. [PMID:30074791]

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