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sphingomyelin synthase 1

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Target not currently curated in GtoImmuPdb

Target id: 2520

Nomenclature: sphingomyelin synthase 1

Family: Sphingomyelin synthase

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 5 413 10q11.23 SGMS1 sphingomyelin synthase 1
Mouse 5 419 19 C1 Sgms1 sphingomyelin synthase 1
Rat 5 419 1q52 Sgms1 sphingomyelin synthase 1
Previous and Unofficial Names Click here for help
Phosphatidylcholine:ceramide cholinephosphotransferase 1 | Protein Mob | SMS1 | TMEM23 | transmembrane protein 23
Database Links Click here for help
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction Click here for help
EC Number: ceramide + phosphatidylcholine -> sphingomyelin + diacylglycerol

Download all structure-activity data for this target as a CSV file go icon to follow link

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 1j [PMID: 26314925] Small molecule or natural product Hs Inhibition 5.7 pIC50 1
pIC50 5.7 (IC50 2.1x10-6 M) [1]
sphingomyelin synthase 2 inhibitor 15w Small molecule or natural product Click here for species-specific activity table Immunopharmacology Ligand Hs Inhibition 4.3 pIC50 2
pIC50 4.3 (IC50 5.6x10-5 M) [2]
Description: Inhibition of purified human SMS1 in vitro.
Immuno Process Associations
Immuno Process:  Inflammation
Immuno Process:  Cytokine production & signalling


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1. Li YL, Qi XY, Jiang H, Deng XD, Dong YP, Ding TB, Zhou L, Men P, Chu Y, Wang RX et al.. (2015) Discovery, synthesis and biological evaluation of 2-(4-(N-phenethylsulfamoyl)phenoxy)acetamides (SAPAs) as novel sphingomyelin synthase 1 inhibitors. Bioorg Med Chem, 23 (18): 6173-84. [PMID:26314925]

2. Mo M, Yang J, Jiang XC, Cao Y, Fei J, Chen Y, Qi X, Chu Y, Zhou L, Ye D. (2018) Discovery of 4-Benzyloxybenzo[ d]isoxazole-3-amine Derivatives as Highly Selective and Orally Efficacious Human Sphingomyelin Synthase 2 Inhibitors that Reduce Chronic Inflammation in db/ db Mice. J Med Chem, 61 (18): 8241-8254. [PMID:30074791]

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