Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	6	365	4q25	SGMS2	sphingomyelin synthase 2
Mouse	6	365	3 G3	Sgms2	sphingomyelin synthase 2
Rat	6	365	2q43	Sgms2	sphingomyelin synthase 2

Previous and Unofficial Names

Phosphatidylcholine:ceramide cholinephosphotransferase 2 | SMS2

Database Links
Alphafold	Q8NHU3 (Hs), Q9D4B1 (Mm), Q4JM44 (Rn)
BRENDA	2.7.8.27
ChEMBL Target	CHEMBL3112379 (Hs), CHEMBL4523444 (Mm)
Ensembl Gene	ENSG00000164023 (Hs), ENSMUSG00000050931 (Mm), ENSRNOG00000011284 (Rn)
Entrez Gene	166929 (Hs), 74442 (Mm), 310849 (Rn)
Human Protein Atlas	ENSG00000164023 (Hs)
KEGG Enzyme	2.7.8.27
KEGG Gene	hsa:166929 (Hs), mmu:74442 (Mm), rno:310849 (Rn)
OMIM	611574 (Hs)
Pharos	Q8NHU3 (Hs)
RefSeq Nucleotide	NM_001136258 (Hs), NM_152621 (Hs), NM_001136257 (Hs), NM_028943 (Mm), NM_001014043 (Rn)
RefSeq Protein	NP_689834 (Hs), NP_001129730 (Hs), NP_001129729 (Hs), NP_083219 (Mm), NP_001014065 (Rn)
UniProtKB	Q8NHU3 (Hs), Q9D4B1 (Mm), Q4JM44 (Rn)
Wikipedia	SGMS2 (Hs)

Enzyme Reaction
EC Number: 2.7.8.27 ceramide + phosphatidylcholine -> sphingomyelin + diacylglycerol

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference sphingomyelin synthase 2 inhibitor 15w Hs Inhibition 7.0 pIC50 3 ⤷ pIC50 7.0 (IC50 1x10-7 M) [3] Description: Inhibition of purified human SMS2 in vitro. compound D24 [PMID: 24374347] Hs Inhibition 4.9 pIC50 2 ⤷ pIC50 4.9 (IC50 1.24x10-5 M) [2]

Immunopharmacology Comments

Sphingomyelin synthase 2 (SMS2) is a promising therapeutic target for chronic inflammation-associated diseases, such as atherosclerosis, fatty liver and insulin resistance. Since downregulation of SMS2 activity results in protective effects against obesity, atherosclerosis and diabetes, selective SMS2 inhibitors are being explored as novel alternatives for the treatment of such metabolic diseases [1].