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Gene and Protein Information ![]() |
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Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | 6 | 365 | 4q25 | SGMS2 | sphingomyelin synthase 2 | |
Mouse | 6 | 365 | 3 G3 | Sgms2 | sphingomyelin synthase 2 | |
Rat | 6 | 365 | 2q43 | Sgms2 | sphingomyelin synthase 2 |
Previous and Unofficial Names ![]() |
Phosphatidylcholine:ceramide cholinephosphotransferase 2 | SMS2 |
Database Links ![]() |
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Alphafold | Q8NHU3 (Hs), Q9D4B1 (Mm), Q4JM44 (Rn) |
BRENDA | 2.7.8.27 |
ChEMBL Target | CHEMBL3112379 (Hs), CHEMBL4523444 (Mm) |
Ensembl Gene | ENSG00000164023 (Hs), ENSMUSG00000050931 (Mm), ENSRNOG00000011284 (Rn) |
Entrez Gene | 166929 (Hs), 74442 (Mm), 310849 (Rn) |
Human Protein Atlas | ENSG00000164023 (Hs) |
KEGG Enzyme | 2.7.8.27 |
KEGG Gene | hsa:166929 (Hs), mmu:74442 (Mm), rno:310849 (Rn) |
OMIM | 611574 (Hs) |
Pharos | Q8NHU3 (Hs) |
RefSeq Nucleotide | NM_001136258 (Hs), NM_152621 (Hs), NM_001136257 (Hs), NM_028943 (Mm), NM_001014043 (Rn) |
RefSeq Protein | NP_689834 (Hs), NP_001129730 (Hs), NP_001129729 (Hs), NP_083219 (Mm), NP_001014065 (Rn) |
UniProtKB | Q8NHU3 (Hs), Q9D4B1 (Mm), Q4JM44 (Rn) |
Wikipedia | SGMS2 (Hs) |
Enzyme Reaction ![]() |
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Download all structure-activity data for this target as a CSV file
Inhibitors | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Immunopharmacology Comments |
Sphingomyelin synthase 2 (SMS2) is a promising therapeutic target for chronic inflammation-associated diseases, such as atherosclerosis, fatty liver and insulin resistance. Since downregulation of SMS2 activity results in protective effects against obesity, atherosclerosis and diabetes, selective SMS2 inhibitors are being explored as novel alternatives for the treatment of such metabolic diseases [1]. |
1. Chen Y, Cao Y. (2017) The sphingomyelin synthase family: proteins, diseases, and inhibitors. Biol Chem, 398 (12): 1319-1325. [PMID:28742512]
2. Deng X, Lin F, Zhang Y, Li Y, Zhou L, Lou B, Li Y, Dong J, Ding T, Jiang X et al.. (2014) Identification of small molecule sphingomyelin synthase inhibitors. Eur J Med Chem, 73: 1-7. [PMID:24374347]
3. Mo M, Yang J, Jiang XC, Cao Y, Fei J, Chen Y, Qi X, Chu Y, Zhou L, Ye D. (2018) Discovery of 4-Benzyloxybenzo[ d]isoxazole-3-amine Derivatives as Highly Selective and Orally Efficacious Human Sphingomyelin Synthase 2 Inhibitors that Reduce Chronic Inflammation in db/ db Mice. J Med Chem, 61 (18): 8241-8254. [PMID:30074791]