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thyroid peroxidase

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Target not currently curated in GtoImmuPdb

Target id: 2526

Nomenclature: thyroid peroxidase

Abbreviated Name: TPO

Family: Thyroid hormone turnover

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 933 2p25.3 TPO thyroid peroxidase
Mouse 1 914 12 13.0 cM Tpo thyroid peroxidase
Rat 1 914 6q16 Tpo thyroid peroxidase
Previous and Unofficial Names Click here for help
Iodide peroxidase | TPX
Database Links Click here for help
BRENDA 1.11.1.8
CATH/Gene3D 1.10.640.10
ChEMBL Target CHEMBL1839 (Hs)
DrugBank Target P07202 (Hs)
Ensembl Gene ENSG00000115705 (Hs), ENSMUSG00000020673 (Mm), ENSRNOG00000004646 (Rn)
Entrez Gene 7173 (Hs), 22018 (Mm), 54314 (Rn)
Human Protein Atlas ENSG00000115705 (Hs)
KEGG Enzyme 1.11.1.8
KEGG Gene hsa:7173 (Hs), mmu:22018 (Mm), rno:54314 (Rn)
OMIM 606765 (Hs)
Orphanet ORPHA120233 (Hs)
Pharos P07202 (Hs)
RefSeq Nucleotide NM_000547 (Hs), NM_001206744 (Hs), NM_001206745 (Hs), NM_175719 (Hs), NM_175722 (Hs), NM_175721 (Hs), NM_009417 (Mm), NM_019353 (Rn)
RefSeq Protein NP_001193674 (Hs), NP_000538 (Hs), NP_001193673 (Hs), NP_783650 (Hs), NP_783652 (Hs), NP_783653 (Hs), NP_033443 (Mm), NP_062226 (Rn)
UniProtKB P07202 (Hs), P35419 (Mm), P14650 (Rn)
Wikipedia TPO (Hs)
Enzyme Reaction Click here for help
EC Number: 1.11.1.8 [Thyroglobulin]-L-tyrosine + H2O2 + H+ + I- -> [Thyroglobulin]-3,5,3'-triiodo-L-thyronine + [thyroglobulin]-aminoacrylate + H2O
Cofactors Click here for help
Cofactor Species Comments Reference
Ca2+ Human Intracellular

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
methimazole Small molecule or natural product Approved drug Primary target of this compound Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibition - - 1
⤷ [1]
propylthiouracil Small molecule or natural product Approved drug Primary target of this compound Ligand has a PDB structure Hs Inhibition - - 1
⤷ [1]
Immuno Process Associations
Immuno Process:  Immune system development
GO Annotations:  Associated to 1 GO processes
GO:0035162 embryonic hemopoiesis IDA
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Thyroid dyshormonogenesis 2A; TDH2A
OMIM: 274500
Orphanet: ORPHA95716

References

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1. Nakashima T, Taurog A, Riesco G. (1978) Mechanism of action of thioureylene antithyroid drugs: factors affecting intrathyroidal metabolism of propylthiouracil and methimazole in rats. Endocrinology, 103 (6): 2187-97. [PMID:748042]

How to cite this page

Thyroid hormone turnover: thyroid peroxidase. Last modified on 07/03/2014. Accessed on 04/12/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2526.