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thyroid peroxidase

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Target not currently curated in GtoImmuPdb

Target id: 2526

Nomenclature: thyroid peroxidase

Abbreviated Name: TPO

Family: Thyroid hormone turnover

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 933 2p25.3 TPO thyroid peroxidase
Mouse 1 914 12 13.0 cM Tpo thyroid peroxidase
Rat 1 914 6q16 Tpo thyroid peroxidase
Previous and Unofficial Names Click here for help
Iodide peroxidase | TPX
Database Links Click here for help
Alphafold P07202 (Hs), P35419 (Mm), P14650 (Rn)
BRENDA 1.11.1.8
CATH/Gene3D 1.10.640.10
ChEMBL Target CHEMBL1839 (Hs)
DrugBank Target P07202 (Hs)
Ensembl Gene ENSG00000115705 (Hs), ENSMUSG00000020673 (Mm), ENSRNOG00000004646 (Rn)
Entrez Gene 7173 (Hs), 22018 (Mm), 54314 (Rn)
Human Protein Atlas ENSG00000115705 (Hs)
KEGG Enzyme 1.11.1.8
KEGG Gene hsa:7173 (Hs), mmu:22018 (Mm), rno:54314 (Rn)
OMIM 606765 (Hs)
Orphanet ORPHA120233 (Hs)
Pharos P07202 (Hs)
RefSeq Nucleotide NM_175722 (Hs), NM_000547 (Hs), NM_001206744 (Hs), NM_001206745 (Hs), NM_175719 (Hs), NM_175721 (Hs), NM_009417 (Mm), NM_019353 (Rn)
RefSeq Protein NP_001193673 (Hs), NP_000538 (Hs), NP_001193674 (Hs), NP_783650 (Hs), NP_783652 (Hs), NP_783653 (Hs), NP_033443 (Mm), NP_062226 (Rn)
UniProtKB P07202 (Hs), P35419 (Mm), P14650 (Rn)
Wikipedia TPO (Hs)
Enzyme Reaction Click here for help
EC Number: 1.11.1.8 [Thyroglobulin]-L-tyrosine + H2O2 + H+ + I- -> [Thyroglobulin]-3,5,3'-triiodo-L-thyronine + [thyroglobulin]-aminoacrylate + H2O
Cofactors Click here for help
Cofactor Species Comments Reference
Ca2+ Human Intracellular

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
mitiperstat Small molecule or natural product Click here for species-specific activity table Hs Inhibition 6.2 pIC50 1
⤷ pIC50 6.2 (IC50 6.9x10-7 M) [1]
methimazole Small molecule or natural product Approved drug Primary target of this compound Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibition - - 2
⤷ [2]
propylthiouracil Small molecule or natural product Approved drug Primary target of this compound Ligand has a PDB structure Hs Inhibition - - 2
⤷ [2]
Immuno Process Associations
Immuno Process:  Immune system development
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Thyroid dyshormonogenesis 2A; TDH2A
OMIM: 274500
Orphanet: ORPHA95716

References

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1. Inghardt T, Antonsson T, Ericsson C, Hovdal D, Johannesson P, Johansson C, Jurva U, Kajanus J, Kull B, Michaëlsson E et al.. (2022) Discovery of AZD4831, a Mechanism-Based Irreversible Inhibitor of Myeloperoxidase, As a Potential Treatment for Heart Failure with Preserved Ejection Fraction. J Med Chem, [Epub ahead of print]. DOI: 10.1021/acs.jmedchem.1c02141 [PMID:36005476]

2. Nakashima T, Taurog A, Riesco G. (1978) Mechanism of action of thioureylene antithyroid drugs: factors affecting intrathyroidal metabolism of propylthiouracil and methimazole in rats. Endocrinology, 103 (6): 2187-97. [PMID:748042]

How to cite this page

Thyroid hormone turnover: thyroid peroxidase. Last modified on 26/08/2022. Accessed on 29/11/2022. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2526.