Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	1	933	2p25.3	TPO	thyroid peroxidase
Mouse	1	914	12 13.0 cM	Tpo	thyroid peroxidase
Rat	1	914	6q16	Tpo	thyroid peroxidase

Previous and Unofficial Names

Iodide peroxidase | TPX

Database Links
Alphafold	P07202 (Hs), P35419 (Mm), P14650 (Rn)
BRENDA	1.11.1.8
CATH/Gene3D	1.10.640.10
ChEMBL Target	CHEMBL1839 (Hs)
DrugBank Target	P07202 (Hs)
Ensembl Gene	ENSG00000115705 (Hs), ENSMUSG00000020673 (Mm), ENSRNOG00000004646 (Rn)
Entrez Gene	7173 (Hs), 22018 (Mm), 54314 (Rn)
Human Protein Atlas	ENSG00000115705 (Hs)
KEGG Enzyme	1.11.1.8
KEGG Gene	hsa:7173 (Hs), mmu:22018 (Mm), rno:54314 (Rn)
OMIM	606765 (Hs)
Orphanet	ORPHA120233 (Hs)
Pharos	P07202 (Hs)
RefSeq Nucleotide	NM_175722 (Hs), NM_000547 (Hs), NM_001206744 (Hs), NM_001206745 (Hs), NM_175719 (Hs), NM_175721 (Hs), NM_009417 (Mm), NM_019353 (Rn)
RefSeq Protein	NP_001193673 (Hs), NP_000538 (Hs), NP_001193674 (Hs), NP_783650 (Hs), NP_783652 (Hs), NP_783653 (Hs), NP_033443 (Mm), NP_062226 (Rn)
UniProtKB	P07202 (Hs), P35419 (Mm), P14650 (Rn)
Wikipedia	TPO (Hs)

Enzyme Reaction
EC Number: 1.11.1.8 [Thyroglobulin]-L-tyrosine + H2O2 + H+ + I- -> [Thyroglobulin]-3,5,3'-triiodo-L-thyronine + [thyroglobulin]-aminoacrylate + H2O

Cofactors
Cofactor Species Comments Reference Ca2+ Human Intracellular

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference methimazole Hs Inhibition - - 1 ⤷ [1] propylthiouracil Hs Inhibition - - 1 ⤷ [1]

Immuno Process Associations

Immuno Process:  Immune system development GO Annotations:  Associated to 1 GO processes GO:0035162 embryonic hemopoiesis IDA

Clinically-Relevant Mutations and Pathophysiology
Disease:  Thyroid dyshormonogenesis 2A; TDH2A OMIM: 274500 Orphanet: ORPHA95716