Top ▲

retinol binding protein 4

Click here for help

Target not currently curated in GtoImmuPdb

Target id: 2549

Nomenclature: retinol binding protein 4

Family: Fatty acid-binding proteins

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 201 10q23.33 RBP4 retinol binding protein 4
Mouse - 201 19 32.75 cM Rbp4 retinol binding protein 4, plasma
Rat - 201 1q53 Rbp4 retinol binding protein 4
Previous and Unofficial Names Click here for help
PRBP | RBPA | retinol binding protein 4, plasma
Database Links Click here for help
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
SynPHARM
UniProtKB
Wikipedia
Selected 3D Structures Click here for help
Image of receptor 3D structure from RCSB PDB
Description:  Crystal structure of retinol-binding protein 4 (RBP4) in complex with non-retinoid ligand.
PDB Id:  3FMZ
Ligand:  A1120
Resolution:  2.9Å
Species:  Human
References:  1

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
A1120 Small molecule or natural product Ligand has a PDB structure Hs Inhibition 7.8 pIC50 2
pIC50 7.8 (IC50 1.4x10-8 M) [2]
Description: Measured using a FRET assay to monitor human RBP4–transthyretin interaction.
Immuno Process Associations
Immuno Process:  B cell (activation)
GO Annotations:  Associated to 1 GO processes
GO:0051024 positive regulation of immunoglobulin secretion ISS
Immuno Process:  Immune regulation
GO Annotations:  Associated to 1 GO processes
GO:0051024 positive regulation of immunoglobulin secretion ISS

References

Show »

1. Motani A, Wang Z, Conn M, Siegler K, Zhang Y, Liu Q, Johnstone S, Xu H, Thibault S, Wang Y et al.. (2009) Identification and characterization of a non-retinoid ligand for retinol-binding protein 4 which lowers serum retinol-binding protein 4 levels in vivo. J. Biol. Chem., 284 (12): 7673-80. [PMID:19147488]

2. Wang Y, Connors R, Fan P, Wang X, Wang Z, Liu J, Kayser F, Medina JC, Johnstone S, Xu H et al.. (2014) Structure-assisted discovery of the first non-retinoid ligands for Retinol-Binding Protein 4. Bioorg. Med. Chem. Lett., 24 (13): 2885-91. [PMID:24835984]

How to cite this page

Fatty acid-binding proteins: retinol binding protein 4. Last modified on 29/01/2016. Accessed on 23/11/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2549.