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Target not currently curated in GtoImmuPdb

Target id: 260

Nomenclature: GPRC5C

Family: Class C Orphans

Gene and Protein Information Click here for help
class C G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 441 17q25.1 GPRC5C G protein-coupled receptor class C group 5 member C 2
Mouse 7 440 11 E2 Gprc5c G protein-coupled receptor, family C, group 5, member C
Rat 7 441 10q32.1 Gprc5c G protein-coupled receptor, class C, group 5, member C
Previous and Unofficial Names Click here for help
RAIG3 | retinoic acid-induced gene 3 protein | G protein-coupled receptor, family C, group 5, member C | G protein-coupled receptor, class C, group 5, member C | G protein-coupled receptor
Database Links Click here for help
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
RefSeq Nucleotide
RefSeq Protein
Tissue Distribution Click here for help
Highest expression in adult cerebellum, spinal cord, liver, lung, kidney, pancreas, spleen, stomach and prostate.
Species:  Human
Technique:  RT-PCR
References:  2
High expression in adult kidney, pancreas and prostate.
Medium expression in adult liver and spleen.
Low expression in colon, small intestine and testis.
Not detectable in brain, heart, lung, placenta, skeletal muscle, ovary, leukocyte and thymus.
Species:  Human
Technique:  RT-PCR
References:  1
Expression Datasets Click here for help

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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General Comments
Orphan receptor.
mRNA expression is induced by retinoic acid in some cell lines.
Hyaluronic acid in the extracellular matrix of the bone marrow is reported to promote haematopoietic stem cell dormancy via interaction with GPRC5C [3]


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1. Bräuner-Osborne H, Jensen AA, Sheppard PO, Brodin B, Krogsgaard-Larsen P, O'Hara P. (2001) Cloning and characterization of a human orphan family C G-protein coupled receptor GPRC5D. Biochim Biophys Acta, 1518: 237-248. [PMID:11311935]

2. Robbins MJ, Michalovich D, Hill J, Calver AR, Medhurst AD, Gloger I, Sims M, Middlemiss DN, Pangalos MN. (2000) Molecular cloning and characterization of two novel retinoic acid-inducible orphan G-protein-coupled receptors (GPRC5B and GPRC5C). Genomics, 67 (1): 8-18. [PMID:10945465]

3. Zhang YW, Mess J, Aizarani N, Mishra P, Johnson C, Romero-Mulero MC, Rettkowski J, Schönberger K, Obier N, Jäcklein K et al.. (2022) Hyaluronic acid-GPRC5C signalling promotes dormancy in haematopoietic stem cells. Nat Cell Biol, 24 (7): 1038-1048. [PMID:35725769]


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