<i>GPRC5D</i> | Class C Orphans | IUPHAR/BPS Guide to PHARMACOLOGY

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Target not currently curated in GtoImmuPdb

Target id: 261

Nomenclature: GPRC5D

Family: Class C Orphans

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

Gene and Protein Information
class C G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 300 12p13.3 GPRC5D G protein-coupled receptor class C group 5 member D 1
Mouse 7 345 6 G1 Gprc5d G protein-coupled receptor 1
Rat 7 332 4q43 Gprc5d G protein-coupled receptor
Previous and Unofficial Names
RAIG4 | G protein-coupled receptor, class C, group 5, member D | G protein-coupled receptor
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
RefSeq Nucleotide
RefSeq Protein
Tissue Distribution
High expression in adult pancreas.
Medium expression in adult kidney, small intestine, spleen and testis.
Low in lung, colon, leukocyte, prostate and thymus and not detectable in brain, heart, liver, placenta, skeletal muscle and ovary.
Species:  Human
Technique:  RT-PCR
References:  1
Expression Datasets

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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General Comments
Orphan receptor.
Although it shares similarities with the retinoic acid induced genes, there is actually no evidence this gene is induced by retinoic acid.


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1. Bräuner-Osborne H, Jensen AA, Sheppard PO, Brodin B, Krogsgaard-Larsen P, O'Hara P. (2001) Cloning and characterization of a human orphan family C G-protein coupled receptor GPRC5D. Biochim Biophys Acta., 1518: 237-248. [PMID:11311935]


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