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Target not currently curated in GtoImmuPdb

Target id: 261

Nomenclature: GPRC5D

Family: Class C Orphans

Gene and Protein Information Click here for help
class C G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 345 12p13.1 GPRC5D G protein-coupled receptor class C group 5 member D 1
Mouse 7 344 6 G1 Gprc5d G protein-coupled receptor, family C, group 5, member D 1
Rat 7 332 4q43 Gprc5d G protein-coupled receptor, class C, group 5, member D
Previous and Unofficial Names Click here for help
RAIG4 | G protein-coupled receptor, class C, group 5, member D | G protein-coupled receptor
Database Links Click here for help
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
RefSeq Nucleotide
RefSeq Protein
Tissue Distribution Click here for help
High expression in adult pancreas.
Medium expression in adult kidney, small intestine, spleen and testis.
Low in lung, colon, leukocyte, prostate and thymus and not detectable in brain, heart, liver, placenta, skeletal muscle and ovary.
Species:  Human
Technique:  RT-PCR
References:  1
Expression Datasets Click here for help

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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General Comments
Orphan receptor.
Although it shares similarities with the retinoic acid induced genes, there is actually no evidence this gene is induced by retinoic acid.


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1. Bräuner-Osborne H, Jensen AA, Sheppard PO, Brodin B, Krogsgaard-Larsen P, O'Hara P. (2001) Cloning and characterization of a human orphan family C G-protein coupled receptor GPRC5D. Biochim Biophys Acta, 1518: 237-248. [PMID:11311935]


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