Gene and Protein Information
class C G protein-coupled receptor
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	7	345	12p13.1	GPRC5D	G protein-coupled receptor class C group 5 member D	2
Mouse	7	344	6 G1	Gprc5d	G protein-coupled receptor, family C, group 5, member D	2
Rat	7	332	4q43	Gprc5d	G protein-coupled receptor, class C, group 5, member D

Previous and Unofficial Names

RAIG4 | G protein-coupled receptor, class C, group 5, member D | G protein-coupled receptor

Database Links
Alphafold	Q9NZD1 (Hs), Q9JIL6 (Mm)
ChEMBL Target	CHEMBL4523925 (Hs)
Ensembl Gene	ENSG00000111291 (Hs), ENSMUSG00000030205 (Mm), ENSRNOG00000008439 (Rn)
Entrez Gene	55507 (Hs), 93746 (Mm), 500349 (Rn)
Human Protein Atlas	ENSG00000111291 (Hs)
KEGG Gene	hsa:55507 (Hs), mmu:93746 (Mm), rno:500349 (Rn)
OMIM	607437 (Hs)
Pharos	Q9NZD1 (Hs)
RefSeq Nucleotide	NM_018654 (Hs), NM_053118 (Mm), NM_001109254 (Rn)
RefSeq Protein	NP_061124 (Hs), NP_444348 (Mm), NP_001102724 (Rn)
UniProtKB	Q9NZD1 (Hs), Q9JIL6 (Mm)
Wikipedia	GPRC5D (Hs)

Download all structure-activity data for this target as a CSV file

Antibodies
Key to terms and symbols		Click column headers to sort
Antibody Sp. Action Value Parameter Reference talquetamab Hs Binding - - 1,3 ⤷ [1,3]

Tissue Distribution
High expression in adult pancreas. Medium expression in adult kidney, small intestine, spleen and testis. Low in lung, colon, leukocyte, prostate and thymus and not detectable in brain, heart, liver, placenta, skeletal muscle and ovary. Species:  Human Technique:  RT-PCR References:  2

Expression Datasets
Show »« Hide Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website] There should be a chart of expression data here, you may need to enable JavaScript!

General Comments
Orphan receptor. Although it shares similarities with the retinoic acid induced genes, there is actually no evidence this gene is induced by retinoic acid.