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lysine demethylase 7A

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Target not currently curated in GtoImmuPdb

Target id: 2686

Nomenclature: lysine demethylase 7A

Family: 1.14.11.- Histone demethylases

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 941 7q34 KDM7A lysine demethylase 7A
Mouse - 940 6 B1 Kdm7a lysine (K)-specific demethylase 7A
Previous and Unofficial Names Click here for help
lysine (K)-specific demethylase 7A
Database Links Click here for help
Alphafold Q6ZMT4 (Hs)
BRENDA 1.14.11.-
CATH/Gene3D 3.30.40.10
ChEMBL Target CHEMBL2163177 (Hs)
Ensembl Gene ENSG00000006459 (Hs), ENSMUSG00000042599 (Mm)
Entrez Gene 80853 (Hs), 338523 (Mm)
Human Protein Atlas ENSG00000006459 (Hs)
KEGG Enzyme 1.14.11.-
KEGG Gene hsa:80853 (Hs), mmu:338523 (Mm)
Pharos Q6ZMT4 (Hs)
RefSeq Nucleotide NM_030647 (Hs), NM_001033430 (Mm)
RefSeq Protein NP_085150 (Hs), NP_001028602 (Mm)
UniProtKB Q6ZMT4 (Hs)
Wikipedia KDM7A (Hs)
Enzyme Reaction Click here for help
EC Number: 1.14.11.-

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
daminozide Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 5.7 pIC50 1
⤷ pIC50 5.7 (IC50 2.1x10-6 M) [1]
General Comments
KDM7A is a dual-specificity H3K9/H3K27 demethylase.

References

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1. Rose NR, Woon EC, Tumber A, Walport LJ, Chowdhury R, Li XS, King ON, Lejeune C, Ng SS, Krojer T et al.. (2012) Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases. J Med Chem, 55 (14): 6639-43. [PMID:22724510]

How to cite this page

1.14.11.- Histone demethylases: lysine demethylase 7A. Last modified on 30/03/2016. Accessed on 19/09/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2686.