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nuclear receptor coactivator 1

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Target not currently curated in GtoImmuPdb

Target id: 2693

Nomenclature: nuclear receptor coactivator 1

Family: 2.3.1.48 Histone acetyltransferases (HATs)

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1441 2p23.3 NCOA1 nuclear receptor coactivator 1
Mouse - 1447 12 A1.1 Ncoa1 nuclear receptor coactivator 1
Rat - 1417 6q14 Ncoa1 nuclear receptor coactivator 1
Previous and Unofficial Names Click here for help
F-SRC-1 | KAT13A | SRC1
Database Links Click here for help
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 2.3.1.48

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 26 [PMID: 21733693] Small molecule or natural product Hs Inhibition 8.0 pIC50 1
pIC50 8.0 (IC50 1x10-8 M) [1]
Phenotypes, Alleles and Disease Models Click here for help Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Ncoa1tm1Bwo|Ncoa2tm1.1Ipc|Pgr+|Pgrtm2(cre)Lyd Ncoa1tm1Bwo/Ncoa1tm1Bwo,Ncoa2tm1.1Ipc/Ncoa2tm1.1Ipc,Pgrtm2(cre)Lyd/Pgr+
involves: 129/Sv * 129S1/Sv * 129S2/SvPas * 129X1/SvJ
MGI:1276523  MGI:1276533  MGI:97567  MP:0003845 abnormal decidualization PMID: 17045797 
Ncoa1tm1Bwo|Thrbtm1Olc Ncoa1tm1Bwo/Ncoa1tm1Bwo,Thrbtm1Olc/Thrbtm1Olc
B6.129-Ncoa1 Thrb
MGI:1276523  MGI:98743  MP:0003638 abnormal response/metabolism to endogenous compounds PMID: 12576486 
Ncoa1tm1Bwo|Thratm2Jas Ncoa1tm1Bwo/Ncoa1tm1Bwo,Thratm2Jas/Thratm2Jas
B6.129-Thra Ncoa1
MGI:1276523  MGI:98742  MP:0003638 abnormal response/metabolism to endogenous compounds PMID: 12576486 
Ncoa1tm1Bwo|Thratm2Jas Ncoa1tm1Bwo/Ncoa1tm1Bwo,Thratm2Jas/Thratm2Jas
B6.129-Thra Ncoa1
MGI:1276523  MGI:98742  MP:0005119 decreased circulating thyroid-stimulating hormone level PMID: 12576486 
Ncoa1tm1Bwo|Thrbtm1Olc Ncoa1tm1Bwo/Ncoa1tm1Bwo,Thrbtm1Olc/Thrbtm1Olc
B6.129-Ncoa1 Thrb
MGI:1276523  MGI:98743  MP:0005122 increased circulating thyroid-stimulating hormone level PMID: 12576486 
Ncoa1tm1Bwo|Thratm2Jas Ncoa1tm1Bwo/Ncoa1tm1Bwo,Thratm2Jas/Thratm2Jas
B6.129-Thra Ncoa1
MGI:1276523  MGI:98742  MP:0005122 increased circulating thyroid-stimulating hormone level PMID: 12576486 
Ncoa1tm1Bwo|Thrbtm1Olc Ncoa1tm1Bwo/Ncoa1tm1Bwo,Thrbtm1Olc/Thrbtm1Olc
B6.129-Ncoa1 Thrb
MGI:1276523  MGI:98743  MP:0005477 increased circulating thyroxine level PMID: 12576486 
Ncoa1tm1Bwo|Thratm2Jas Ncoa1tm1Bwo/Ncoa1tm1Bwo,Thratm2Jas/Thratm2Jas
B6.129-Thra Ncoa1
MGI:1276523  MGI:98742  MP:0005477 increased circulating thyroxine level PMID: 12576486 
Ncoa1tm1Bwo|Thrbtm1Olc Ncoa1tm1Bwo/Ncoa1tm1Bwo,Thrbtm1Olc/Thrbtm1Olc
B6.129-Ncoa1 Thrb
MGI:1276523  MGI:98743  MP:0005480 increased circulating triiodothyronine level PMID: 12576486 
Ncoa1tm1Bwo|Thratm2Jas Ncoa1tm1Bwo/Ncoa1tm1Bwo,Thratm2Jas/Thratm2Jas
B6.129-Thra Ncoa1
MGI:1276523  MGI:98742  MP:0005480 increased circulating triiodothyronine level PMID: 12576486 

References

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1. Stellwagen JC, Adjabeng GM, Arnone MR, Dickerson SH, Han C, Hornberger KR, King AJ, Mook Jr RA, Petrov KG, Rheault TR et al.. (2011) Development of potent B-RafV600E inhibitors containing an arylsulfonamide headgroup. Bioorg Med Chem Lett, 21 (15): 4436-40. [PMID:21733693]

How to cite this page

2.3.1.48 Histone acetyltransferases (HATs): nuclear receptor coactivator 1. Last modified on 16/09/2015. Accessed on 19/04/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2693.