Top ▲

nuclear receptor coactivator 1

Click here for help

Target not currently curated in GtoImmuPdb

Target id: 2693

Nomenclature: nuclear receptor coactivator 1

Family: 2.3.1.48 Histone acetyltransferases (HATs)

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1441 2p23.3 NCOA1 nuclear receptor coactivator 1
Mouse - 1447 12 A1.1 Ncoa1 nuclear receptor coactivator 1
Rat - 1417 6q14 Ncoa1 nuclear receptor coactivator 1
Previous and Unofficial Names Click here for help
F-SRC-1 | KAT13A | SRC1
Database Links Click here for help
Alphafold Q15788 (Hs), P70365 (Mm)
BRENDA 2.3.1.48
CATH/Gene3D 1.10.287.1070, 4.10.280.10
ChEMBL Target CHEMBL1615387 (Hs)
Ensembl Gene ENSG00000084676 (Hs), ENSMUSG00000020647 (Mm), ENSRNOG00000004068 (Rn)
Entrez Gene 8648 (Hs), 17977 (Mm), 313929 (Rn)
Human Protein Atlas ENSG00000084676 (Hs)
KEGG Enzyme 2.3.1.48
KEGG Gene hsa:8648 (Hs), mmu:17977 (Mm), rno:313929 (Rn)
OMIM 602691 (Hs)
Pharos Q15788 (Hs)
RefSeq Nucleotide NM_003743 (Hs), NM_010881 (Mm), NM_001108012 (Rn)
RefSeq Protein NP_003734 (Hs), NP_035011 (Mm), NP_001101482 (Rn)
UniProtKB Q15788 (Hs), P70365 (Mm)
Wikipedia NCOA1 (Hs)
Enzyme Reaction Click here for help
EC Number: 2.3.1.48

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 26 [PMID: 21733693] Small molecule or natural product Hs Inhibition 8.0 pIC50 1
⤷ pIC50 8.0 (IC50 1x10-8 M) [1]
Phenotypes, Alleles and Disease Models Click here for help Mouse data from MGI

Show »

Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Ncoa1tm1Bwo|Ncoa2tm1.1Ipc|Pgr+|Pgrtm2(cre)Lyd Ncoa1tm1Bwo/Ncoa1tm1Bwo,Ncoa2tm1.1Ipc/Ncoa2tm1.1Ipc,Pgrtm2(cre)Lyd/Pgr+
involves: 129/Sv * 129S1/Sv * 129S2/SvPas * 129X1/SvJ		 MGI:1276523  MGI:1276533  MGI:97567  MP:0003845 abnormal decidualization PMID: 17045797 
Ncoa1tm1Bwo|Thrbtm1Olc Ncoa1tm1Bwo/Ncoa1tm1Bwo,Thrbtm1Olc/Thrbtm1Olc
B6.129-Ncoa1 Thrb		 MGI:1276523  MGI:98743  MP:0003638 abnormal response/metabolism to endogenous compounds PMID: 12576486 
Ncoa1tm1Bwo|Thratm2Jas Ncoa1tm1Bwo/Ncoa1tm1Bwo,Thratm2Jas/Thratm2Jas
B6.129-Thra Ncoa1		 MGI:1276523  MGI:98742  MP:0003638 abnormal response/metabolism to endogenous compounds PMID: 12576486 
Ncoa1tm1Bwo|Thratm2Jas Ncoa1tm1Bwo/Ncoa1tm1Bwo,Thratm2Jas/Thratm2Jas
B6.129-Thra Ncoa1		 MGI:1276523  MGI:98742  MP:0005119 decreased circulating thyroid-stimulating hormone level PMID: 12576486 
Ncoa1tm1Bwo|Thrbtm1Olc Ncoa1tm1Bwo/Ncoa1tm1Bwo,Thrbtm1Olc/Thrbtm1Olc
B6.129-Ncoa1 Thrb		 MGI:1276523  MGI:98743  MP:0005122 increased circulating thyroid-stimulating hormone level PMID: 12576486 
Ncoa1tm1Bwo|Thratm2Jas Ncoa1tm1Bwo/Ncoa1tm1Bwo,Thratm2Jas/Thratm2Jas
B6.129-Thra Ncoa1		 MGI:1276523  MGI:98742  MP:0005122 increased circulating thyroid-stimulating hormone level PMID: 12576486 
Ncoa1tm1Bwo|Thrbtm1Olc Ncoa1tm1Bwo/Ncoa1tm1Bwo,Thrbtm1Olc/Thrbtm1Olc
B6.129-Ncoa1 Thrb		 MGI:1276523  MGI:98743  MP:0005477 increased circulating thyroxine level PMID: 12576486 
Ncoa1tm1Bwo|Thratm2Jas Ncoa1tm1Bwo/Ncoa1tm1Bwo,Thratm2Jas/Thratm2Jas
B6.129-Thra Ncoa1		 MGI:1276523  MGI:98742  MP:0005477 increased circulating thyroxine level PMID: 12576486 
Ncoa1tm1Bwo|Thrbtm1Olc Ncoa1tm1Bwo/Ncoa1tm1Bwo,Thrbtm1Olc/Thrbtm1Olc
B6.129-Ncoa1 Thrb		 MGI:1276523  MGI:98743  MP:0005480 increased circulating triiodothyronine level PMID: 12576486 
Ncoa1tm1Bwo|Thratm2Jas Ncoa1tm1Bwo/Ncoa1tm1Bwo,Thratm2Jas/Thratm2Jas
B6.129-Thra Ncoa1		 MGI:1276523  MGI:98742  MP:0005480 increased circulating triiodothyronine level PMID: 12576486 

References

Show »

1. Stellwagen JC, Adjabeng GM, Arnone MR, Dickerson SH, Han C, Hornberger KR, King AJ, Mook Jr RA, Petrov KG, Rheault TR et al.. (2011) Development of potent B-RafV600E inhibitors containing an arylsulfonamide headgroup. Bioorg Med Chem Lett, 21 (15): 4436-40. [PMID:21733693]

How to cite this page

2.3.1.48 Histone acetyltransferases (HATs): nuclear receptor coactivator 1. Last modified on 16/09/2015. Accessed on 19/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2693.