SET domain containing 7, histone lysine methyltransferase | 2.1.1.43 Histone methyltransferases (HMTs) | IUPHAR/BPS Guide to PHARMACOLOGY

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SET domain containing 7, histone lysine methyltransferase

Target not currently curated in GtoImmuPdb

Target id: 2703

Nomenclature: SET domain containing 7, histone lysine methyltransferase

Family: 2.1.1.43 Histone methyltransferases (HMTs)

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 366 4q31.1 SETD7 SET domain containing 7, histone lysine methyltransferase
Mouse - 366 3 C Setd7 SET domain containing (lysine methyltransferase) 7
Rat - 366 2q26 Setd7 SET domain containing 7, histone lysine methyltransferase
Previous and Unofficial Names
KMT7 | SET7/9 | SET domain containing (lysine methyltransferase) 7 | SET domain containing lysine methyltransferase 7 | SET domain containing 7
Database Links
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
SynPHARM
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 2.1.1.43

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
(R)-PFI-2 Hs Inhibition 9.5 pKi 1
pKi 9.5 (Ki 3.3x10-10 M) [1]

References

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1. Barsyte-Lovejoy D, Li F, Oudhoff MJ, Tatlock JH, Dong A, Zeng H, Wu H, Freeman SA, Schapira M, Senisterra GA et al.. (2014) (R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells. Proc. Natl. Acad. Sci. U.S.A., 111 (35): 12853-8. [PMID:25136132]

How to cite this page

2.1.1.43 Histone methyltransferases (HMTs): SET domain containing 7, histone lysine methyltransferase. Last modified on 27/03/2019. Accessed on 14/11/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2703.