Top ▲

SET domain containing 7, histone lysine methyltransferase

Click here for help

Target not currently curated in GtoImmuPdb

Target id: 2703

Nomenclature: SET domain containing 7, histone lysine methyltransferase

Family: 2.1.1.43 Histone methyltransferases (HMTs)

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 366 4q31.1 SETD7 SET domain containing 7, histone lysine methyltransferase
Mouse - 366 3 C Setd7 SET domain containing (lysine methyltransferase) 7
Rat - 366 2q26 Setd7 SET domain containing 7, histone lysine methyltransferase
Previous and Unofficial Names Click here for help
KMT7 | SET7/9 | SET domain containing (lysine methyltransferase) 7 | SET domain containing lysine methyltransferase 7 | SET domain containing 7
Database Links Click here for help
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
SynPHARM
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 2.1.1.43

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
(R)-PFI-2 Small molecule or natural product Primary target of this compound Ligand has a PDB structure Hs Inhibition 9.5 pKi 1
pKi 9.5 (Ki 3.3x10-10 M) [1]

References

Show »

1. Barsyte-Lovejoy D, Li F, Oudhoff MJ, Tatlock JH, Dong A, Zeng H, Wu H, Freeman SA, Schapira M, Senisterra GA et al.. (2014) (R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells. Proc. Natl. Acad. Sci. U.S.A., 111 (35): 12853-8. [PMID:25136132]

How to cite this page

2.1.1.43 Histone methyltransferases (HMTs): SET domain containing 7, histone lysine methyltransferase. Last modified on 27/03/2019. Accessed on 19/10/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2703.