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Target not currently curated in GtoImmuPdb

Target id: 2746

Nomenclature: ABCC9

Abbreviated Name: SUR2

Family: ABCC subfamily

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 15 1549 12p12.1 ABCC9 ATP binding cassette subfamily C member 9
Mouse 15 1546 6 74.35 cM Abcc9 ATP-binding cassette, sub-family C member 9
Rat 15 1545 4q44 Abcc9 ATP binding cassette subfamily C member 9
Previous and Unofficial Names Click here for help
CDMD10 | sulfonylurea receptor 2 | SUR2 | ATP-binding cassette, sub-family C (CFTR/MRP), member 9 | ATP-binding cassette, subfamily C (CFTR/MRP), member 9 | ATP-binding cassette
Database Links Click here for help
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
RefSeq Nucleotide
RefSeq Protein

Download all structure-activity data for this target as a CSV file go icon to follow link

Allosteric Modulators
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 13b [PMID: 19101153] Small molecule or natural product Hs Positive 6.2 pEC50 2
pEC50 6.2 (EC50 6.7x10-7 M) Compound 13b is a channel opener. [2]
Allosteric Modulator Comments
Compound 13b [PMID: 19101153] is most likely to bind the SUR2 [1] component of the ATP-sensitive potassium channel on smooth muscle cells, causing increased channel opening and cellular hyperpolarisation.
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Atrial fibrillation, familial, 12; ATFB12
Synonyms: Familial atrial fibrillation [Orphanet: ORPHA334] [Disease Ontology: DOID:0050650]
Disease Ontology: DOID:0050650
OMIM: 614050
Orphanet: ORPHA334
Disease:  Cantu Syndrome
Synonyms: Hypertrichotic osteochondrodysplasia, Cantu type [Orphanet: ORPHA1517]
OMIM: 239850
Orphanet: ORPHA1517
Disease:  Cardiomyopathy, dilated, 1O; CMD1O
Synonyms: Dilated cardiomyopathy [Disease Ontology: DOID:12930]
Familial isolated dilated cardiomyopathy [Orphanet: ORPHA154]
Disease Ontology: DOID:12930
OMIM: 608569
Orphanet: ORPHA154


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1. Isomoto S, Kondo C, Yamada M, Matsumoto S, Higashiguchi O, Horio Y, Matsuzawa Y, Kurachi Y. (1996) A novel sulfonylurea receptor forms with BIR (Kir6.2) a smooth muscle type ATP-sensitive K+ channel. J Biol Chem, 271 (40): 24321-4. [PMID:8798681]

2. Zhang X, Qiu Y, Li X, Bhattacharjee S, Woods M, Kraft P, Lundeen SG, Sui Z. (2009) Discovery and structure-activity relationships of a novel series of benzopyran-based K(ATP) openers for urge urinary incontinence. Bioorg Med Chem, 17 (2): 855-66. [PMID:19101153]

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