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kinesin-5

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Target not currently curated in GtoImmuPdb

Target id: 2788

Nomenclature: kinesin-5

Family: Kinesins

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1056 10q23.33 KIF11 kinesin family member 11
Mouse - 1052 19 C2 Kif11 kinesin family member 11
Rat - 1056 1q53 Kif11 kinesin family member 11
Previous and Unofficial Names Click here for help
BimC | Eg5
Database Links Click here for help
Alphafold
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
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Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
AZD4877 Small molecule or natural product Primary target of this compound Hs Inhibition 8.7 pIC50 1
pIC50 8.7 (IC50 2x10-9 M) [1]
Description: Measured as inhibition of ATPase activity of a 369 amino acid N-terminal fragment of hKIF11
Immuno Process Associations
Immuno Process:  Antigen presentation
GO Annotations:  Associated to 1 GO processes
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Microcephaly with or without chorioretinopathy, lymphedema, or mental retardation; MCLMR
Synonyms: Microcephaly - lymphedema - chorioretinopathy [Orphanet: ORPHA2526]
OMIM: 152950
Orphanet: ORPHA2526

References

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1. Theoclitou ME, Aquila B, Block MH, Brassil PJ, Castriotta L, Code E, Collins MP, Davies AM, Deegan T, Ezhuthachan J et al.. (2011) Discovery of (+)-N-(3-aminopropyl)-N-[1-(5-benzyl-3-methyl-4-oxo-[1,2]thiazolo[5,4-d]pyrimidin-6-yl)-2-methylpropyl]-4-methylbenzamide (AZD4877), a kinesin spindle protein inhibitor and potential anticancer agent. J Med Chem, 54 (19): 6734-50. [PMID:21899292]

How to cite this page

Kinesins: kinesin-5. Last modified on 30/03/2017. Accessed on 25/05/2022. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2788.