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Gene and Protein Information ![]() |
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Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | - | 1056 | 10q23.33 | KIF11 | kinesin family member 11 | |
Mouse | - | 1052 | 19 C2 | Kif11 | kinesin family member 11 | |
Rat | - | 1056 | 1q53 | Kif11 | kinesin family member 11 |
Previous and Unofficial Names ![]() |
BimC | Eg5 |
Database Links ![]() |
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Alphafold | P52732 (Hs), Q6P9P6 (Mm) |
CATH/Gene3D | 3.40.850.10 |
ChEMBL Target | CHEMBL4581 (Hs) |
Ensembl Gene | ENSG00000138160 (Hs), ENSMUSG00000012443 (Mm), ENSRNOG00000056069 (Rn) |
Entrez Gene | 3832 (Hs), 16551 (Mm), 171304 (Rn) |
Human Protein Atlas | ENSG00000138160 (Hs) |
KEGG Gene | hsa:3832 (Hs), mmu:16551 (Mm), rno:171304 (Rn) |
OMIM | 148760 (Hs) |
Pharos | P52732 (Hs) |
RefSeq Nucleotide | NM_004523 (Hs), NM_010615 (Mm), NM_001169112 (Rn) |
RefSeq Protein | NP_004514 (Hs), NP_034745 (Mm), NP_001162583 (Rn) |
UniProtKB | P52732 (Hs), Q6P9P6 (Mm) |
Wikipedia | KIF11 (Hs) |
Download all structure-activity data for this target as a CSV file
Inhibitors | |||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||
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Immuno Process Associations | ||
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Clinically-Relevant Mutations and Pathophysiology ![]() |
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1. Theoclitou ME, Aquila B, Block MH, Brassil PJ, Castriotta L, Code E, Collins MP, Davies AM, Deegan T, Ezhuthachan J et al.. (2011) Discovery of (+)-N-(3-aminopropyl)-N-[1-(5-benzyl-3-methyl-4-oxo-[1,2]thiazolo[5,4-d]pyrimidin-6-yl)-2-methylpropyl]-4-methylbenzamide (AZD4877), a kinesin spindle protein inhibitor and potential anticancer agent. J Med Chem, 54 (19): 6734-50. [PMID:21899292]
Kinesins: kinesin-5. Last modified on 30/03/2017. Accessed on 16/02/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2788.