MCH<sub>2</sub> receptor | Melanin-concentrating hormone receptors | IUPHAR/BPS Guide to PHARMACOLOGY

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MCH2 receptor

Target not currently curated in GtoImmuPdb

Target id: 281

Nomenclature: MCH2 receptor

Family: Melanin-concentrating hormone receptors

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 340 6q16.3 MCHR2 melanin concentrating hormone receptor 2 1,6,12-13
Gene and Protein Information Comments
MCHR2 genes have been identified in Xenopus [7], goldfish [11], flounder [15], zebrafish [9] and shark [10].
Previous and Unofficial Names
GPR145 | GPRv17 | MCH2R | G protein-coupled receptor 145 | melanin-concentrating hormone receptor 2
Database Links
Specialist databases
GPCRDB mchr2_human (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
RefSeq Nucleotide
RefSeq Protein
Natural/Endogenous Ligands
melanin-concentrating hormone {Sp: Human, Mouse, Rat}

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
[Phe13,Tyr19]MCH Hs Full agonist 8.4 – 9.2 pIC50 14,16
pIC50 8.4 – 9.2 [14,16]
melanin-concentrating hormone {Sp: Human, Mouse, Rat} Hs Full agonist 8.2 – 9.2 pIC50 14
pIC50 8.2 – 9.2 [14]
Ac-hMCH-(6-16)-NH2 Hs Full agonist 8.4 – 8.8 pIC50 2
pIC50 8.4 – 8.8 [2]
MCH (salmon) Hs Full agonist 6.2 – 7.1 pIC50 14,16
pIC50 6.2 – 7.1 [14,16]
Agonist Comments
Ligand rank potency: melanin-concentrating hormone = MCH (salmon) [6]
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 38 [PMID: 22123324] Hs Antagonist 9.0 pIC50 4
pIC50 9.0 (IC50 1x10-9 M) [4]
[Ava9,10,Ava14,15]-Ac-hMCH6-16-NH2 Hs Antagonist 7.3 pIC50 2
pIC50 7.3 [2]
ATC0065 Hs Antagonist 5.8 – 5.9 pIC50 3
pIC50 5.8 – 5.9 [3]
Primary Transduction Mechanisms
Transducer Effector/Response
Gq/G11 family Adenylate cyclase inhibition
Phospholipase C stimulation
References:  14
Tissue Distribution
Brain; frontal lobe, temporal lobe, occipital lobe, precentral gyrus, pons, hippocampus, amygdala, putamen, and the caudate nucleus, with relatively high levels in the cerebral cortex > thalamus, corpus callosum, and medulla oblongata.

Hypothalamus, adipocytes, pituitary, and pancreas.
Species:  Human
Technique:  RT-PCR, Northern hybridization and RNA dot array blot hybridization.
References:  1
Brain; arcuate nucleus and ventral medial hypothalamus.
Species:  Human
Technique:  Northern Blot and in situ hybridization.
References:  14
Brain (cortex, occipital lobe, frontal lobe, temporal lobe, parietal lobe, paracentral gyrus, cerebellum, amygdala, hippocampus, accumbens nucleus, thalamus).
Species:  Human
Technique:  Northern and dot blot.
References:  16
Brain > adipose tissue > prostate, lymphocytes, intestine. Cingulate gyrus > nucleus accumbens > medial frontal gyrus > superior frontal gyrus.
Species:  Human
Technique:  Quantitative RT-PCR.
References:  6
Brain (temporal lobe, cerebral cortex > hippocampus, parietal lobe, amygdala, corpus callosum, occipital lobe, frontal lobe, caudate nucleus) > tetis.
Species:  Human
Technique:  Quantitative RT-PCR.
References:  12-13
Hypothalamus (paraventricular nucleus (magnocellular part), dorsomedial, ventromedial, and arcuate nucleus), olfactory pathway, nucleus of the solitary tract.

Thyroid, kidney, lung, testis.
Species:  Mouse
Technique:  in situ hybridization.
References:  8
Functional Assays
Measurement of IP3 production in CHO cells transfected with the human NCH2 receptors.
Species:  Human
Tissue:  CHO cells.
Response measured:  Stimulation of IP3 production.
References:  14,16
Measurement of intracellular Ca2+ levels in CHO cells transfected with the human MCH2 receptor.
Species:  Human
Tissue:  CHO cells.
Response measured:  Increase in intracellular Ca2+.
References:  13-14,16
Measurement of intracellular Ca2+ levels in HEK 293 cells transfected with the human MCH2 receptor.
Species:  Human
Tissue:  HEK 293 cells.
Response measured:  Increase in intracellular Ca2+.
References:  6,14
Measurement of cellular extrusion of protons in HEK 293 cells transfected with the human MHC2 receptor.
Species:  Human
Tissue:  HEK 293 cells.
Response measured:  Increase in cellular extrusion of protons.
References:  6
Measurement of inositol phosphate turnover.
Species:  Human
Response measured:  Stimulation of inositol phosphate turnover.
References:  14
Functional Assay Comments
Levels of cAMP accumulation, Ca2+ mobilisation and ERK phosphorylation for exogenously expressed goldfish MCH2 receptors have been measured [5]. Ca2+ mobilisation has been measured in exogenously expressed Xenopus [7] and flounder [15] MCH2 receptors.


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1. An S, Cutler G, Zhao JJ, Huang SG, Tian H, Li W, Liang L, Rich M, Bakleh A, Du J et al.. (2001) Identification and characterization of a melanin-concentrating hormone receptor. Proc. Natl. Acad. Sci. U.S.A., 98 (13): 7576-81. [PMID:11416225]

2. Bednarek MA, Hreniuk DL, Tan C, Palyha OC, MacNeil DJ, Van der Ploeg LH, Howard AD, Feighner SD. (2002) Synthesis and biological evaluation in vitro of selective, high affinity peptide antagonists of human melanin-concentrating hormone action at human melanin-concentrating hormone receptor 1. Biochemistry, 41 (20): 6383-90. [PMID:12009900]

3. Chaki S, Funakoshi T, Hirota-Okuno S, Nishiguchi M, Shimazaki T, Iijima M, Grottick AJ, Kanuma K, Omodera K, Sekiguchi Y, Okuyama S, Tran TA, Semple G, Thomsen W. (2005) Anxiolytic- and antidepressant-like profile of ATC0065 and ATC0175: nonpeptidic and orally active melanin-concentrating hormone receptor 1 antagonists. J Pharmacol Exp Ther, 313: 831-839. [PMID:15677346]

4. Chen X, Mihalic J, Fan P, Liang L, Lindstrom M, Wong S, Ye Q, Fu Y, Jaen J, Chen JL et al.. (2012) Discovery and characterization of a potent and selective antagonist of melanin-concentrating hormone receptor 2. Bioorg. Med. Chem. Lett., 22 (1): 363-6. [PMID:22123324]

5. Hamamoto A, Mizusawa K, Takahashi A, Saito Y. (2011) Signalling pathway of goldfish melanin-concentrating hormone receptors 1 and 2. Regul. Pept., 169 (1-3): 6-12. [PMID:21539863]

6. Hill J, Duckworth M, Murdock P, Rennie G, Sabido-David C, Ames RS, Szekeres P, Wilson S, Bergsma DJ, Gloger IS et al.. (2001) Molecular cloning and functional characterization of MCH2, a novel human MCH receptor. J. Biol. Chem., 276 (23): 20125-9. [PMID:11274220]

7. Kobayashi Y, Hamamoto A, Hirayama T, Saito Y. (2015) Molecular cloning, expression, and signaling pathway of four melanin-concentrating hormone receptors from Xenopus tropicalis. Gen. Comp. Endocrinol., 212: 114-23. [PMID:24662390]

8. Kokkotou EG, Tritos NA, Mastaitis JW, Slieker L, Maratos-Flier E. (2001) Melanin-concentrating hormone receptor is a target of leptin action in the mouse brain. Endocrinology, 142 (2): 680-6. [PMID:11159839]

9. Logan DW, Bryson-Richardson RJ, Pagán KE, Taylor MS, Currie PD, Jackson IJ. (2003) The structure and evolution of the melanocortin and MCH receptors in fish and mammals. Genomics, 81 (2): 184-91. [PMID:12620396]

10. Mizusawa K, Amiya N, Yamaguchi Y, Takabe S, Amano M, Breves JP, Fox BK, Grau EG, Hyodo S, Takahashi A. (2012) Identification of mRNAs coding for mammalian-type melanin-concentrating hormone and its receptors in the scalloped hammerhead shark Sphyrna lewini. Gen. Comp. Endocrinol., 179 (1): 78-87. [PMID:22884735]

11. Mizusawa K, Saito Y, Wang Z, Kobayashi Y, Matsuda K, Takahashi A. (2009) Molecular cloning and expression of two melanin-concentrating hormone receptors in goldfish. Peptides, 30 (11): 1990-6. [PMID:19397943]

12. Mori M, Harada M, Terao Y, Sugo T, Watanabe T, Shimomura Y, Abe M, Shintani Y, Onda H, Nishimura O et al.. (2001) Cloning of a novel G protein-coupled receptor, SLT, a subtype of the melanin-concentrating hormone receptor. Biochem. Biophys. Res. Commun., 283 (5): 1013-8. [PMID:11355873]

13. Rodriguez M, Beauverger P, Naime I, Rique H, Ouvry C, Souchaud S, Dromaint S, Nagel N, Suply T, Audinot V et al.. (2001) Cloning and molecular characterization of the novel human melanin-concentrating hormone receptor MCH2. Mol. Pharmacol., 60 (4): 632-9. [PMID:11562423]

14. Sailer AW, Sano H, Zeng Z, McDonald TP, Pan J, Pong SS, Feighner SD, Tan CP, Fukami T, Iwaasa H et al.. (2001) Identification and characterization of a second melanin-concentrating hormone receptor, MCH-2R. Proc. Natl. Acad. Sci. U.S.A., 98 (13): 7564-9. [PMID:11404457]

15. Takahashi A, Kosugi T, Kobayashi Y, Yamanome T, Schiöth HB, Kawauchi H. (2007) The melanin-concentrating hormone receptor 2 (MCH-R2) mediates the effect of MCH to control body color for background adaptation in the barfin flounder. Gen. Comp. Endocrinol., 151 (2): 210-9. [PMID:17324419]

16. Wang S, Behan J, O'Neill K, Weig B, Fried S, Laz T, Bayne M, Gustafson E, Hawes BE. (2001) Identification and pharmacological characterization of a novel human melanin-concentrating hormone receptor, mch-r2. J. Biol. Chem., 276 (37): 34664-70. [PMID:11459838]


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