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NRAS

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Target not currently curated in GtoImmuPdb

Target id: 2823

Nomenclature: NRAS

Family: RAS subfamily

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 189 1p13.2 NRAS NRAS proto-oncogene, GTPase
Mouse - 189 3 45.25 cM Nras neuroblastoma ras oncogene
Rat - 189 2q34 Nras NRAS proto-oncogene, GTPase
Previous and Unofficial Names Click here for help
N-ras | neuroblastoma ras oncogene | neuroblastoma RAS viral (v-ras) oncogene homolog | neuroblastoma RAS viral oncogene homolog | NRAS proto-oncogene, GTPase | NRAS proto-oncogene
Database Links Click here for help
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
lonafarnib Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 8.6 pIC50 1
pIC50 8.6 (IC50 2.8x10-9 M) [1]
Description: Measuring inhibition of farnesylation of NRAS by human farnesyltransferase
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 2 GO processes
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS
GO:0043312 neutrophil degranulation TAS
Immuno Process:  Immune regulation
GO Annotations:  Associated to 2 GO processes
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS
GO:0050852 T cell receptor signaling pathway IMP
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 3 GO processes
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS
GO:0043312 neutrophil degranulation TAS
GO:0050852 T cell receptor signaling pathway IMP
Immuno Process:  B cell (activation)
GO Annotations:  Associated to 1 GO processes
GO:0042088 T-helper 1 type immune response IMP
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 1 GO processes
GO:0032729 positive regulation of interferon-gamma production IMP
Immuno Process:  T cell (activation)
GO Annotations:  Associated to 1 GO processes
GO:0042088 T-helper 1 type immune response IMP
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Colorectal cancer
Disease Ontology: DOID:9256
OMIM: 114500
Disease:  Juvenile myelomonocytic leukemia; JMML
Disease Ontology: DOID:0050458
OMIM: 607785
Orphanet: ORPHA86834
Disease:  Melanocytic nevus syndrome, congenital; CMNS
Synonyms: Congenital melanocytic nevus [Disease Ontology: DOID:3157]
Large congenital melanocytic nevus [Orphanet: ORPHA626]
Disease Ontology: DOID:3157
OMIM: 137550
Orphanet: ORPHA626
Disease:  Melanosis, neurocutaneous; NCMS
OMIM: 249400
Disease:  Nevus, epidermal
Disease Ontology: DOID:0050532
OMIM: 162900
Disease:  Noonan syndrome 6; NS6
Synonyms: Noonan syndrome [Orphanet: ORPHA648] [Disease Ontology: DOID:3490]
Disease Ontology: DOID:3490
OMIM: 613224
Orphanet: ORPHA648
Disease:  RAS-associated autoimmune leukoproliferative disorder; RALD
OMIM: 614470
Orphanet: ORPHA268114
Disease:  Schimmelpenning-Feuerstein-Mims syndrome; SFM
Synonyms: Linear nevus sebaceus syndrome [Orphanet: ORPHA2612]
OMIM: 163200
Orphanet: ORPHA2612
Disease:  Thyroid carcinoma, follicular; FTC
Synonyms: Differentiated thyroid carcinoma [Orphanet: ORPHA146]
Follicular thyroid carcinoma [Disease Ontology: DOID:3962]
Disease Ontology: DOID:3962
OMIM: 188470
Orphanet: ORPHA146

References

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1. Liu M, Bryant MS, Chen J, Lee S, Yaremko B, Lipari P, Malkowski M, Ferrari E, Nielsen L, Prioli N et al.. (1998) Antitumor activity of SCH 66336, an orally bioavailable tricyclic inhibitor of farnesyl protein transferase, in human tumor xenograft models and wap-ras transgenic mice. Cancer Res., 58 (21): 4947-56. [PMID:9810004]

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