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Target not currently curated in GtoImmuPdb

Target id: 2823

Nomenclature: NRAS

Family: RAS subfamily

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 189 1p13.2 NRAS NRAS proto-oncogene, GTPase
Mouse - 189 3 45.25 cM Nras neuroblastoma ras oncogene
Rat - 189 2q34 Nras NRAS proto-oncogene, GTPase
Previous and Unofficial Names Click here for help
N-ras | neuroblastoma ras oncogene | neuroblastoma RAS viral (v-ras) oncogene homolog | neuroblastoma RAS viral oncogene homolog | NRAS proto-oncogene, GTPase | NRAS proto-oncogene
Database Links Click here for help
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
RefSeq Nucleotide
RefSeq Protein

Download all structure-activity data for this target as a CSV file go icon to follow link

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
lonafarnib Small molecule or natural product Approved drug Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 8.6 pIC50 1
pIC50 8.6 (IC50 2.8x10-9 M) [1]
Description: Measuring inhibition of farnesylation of NRAS by human farnesyltransferase
Immuno Process Associations
Immuno Process:  Inflammation
Immuno Process:  Immune regulation
Immuno Process:  Cellular signalling
Immuno Process:  B cell (activation)
Immuno Process:  Cytokine production & signalling
Immuno Process:  T cell (activation)
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Colorectal cancer
Disease Ontology: DOID:9256
OMIM: 114500
Disease:  Juvenile myelomonocytic leukemia; JMML
Disease Ontology: DOID:0050458
OMIM: 607785
Orphanet: ORPHA86834
Disease:  Melanocytic nevus syndrome, congenital; CMNS
Synonyms: Congenital melanocytic nevus [Disease Ontology: DOID:3157]
Large congenital melanocytic nevus [Orphanet: ORPHA626]
Disease Ontology: DOID:3157
OMIM: 137550
Orphanet: ORPHA626
Disease:  Melanosis, neurocutaneous; NCMS
OMIM: 249400
Disease:  Nevus, epidermal
Disease Ontology: DOID:0050532
OMIM: 162900
Disease:  Noonan syndrome 6; NS6
Synonyms: Noonan syndrome [Orphanet: ORPHA648] [Disease Ontology: DOID:3490]
Disease Ontology: DOID:3490
OMIM: 613224
Orphanet: ORPHA648
Disease:  RAS-associated autoimmune leukoproliferative disorder; RALD
OMIM: 614470
Orphanet: ORPHA268114
Disease:  Schimmelpenning-Feuerstein-Mims syndrome; SFM
Synonyms: Linear nevus sebaceus syndrome [Orphanet: ORPHA2612]
OMIM: 163200
Orphanet: ORPHA2612
Disease:  Thyroid carcinoma, follicular; FTC
Synonyms: Differentiated thyroid carcinoma [Orphanet: ORPHA146]
Follicular thyroid carcinoma [Disease Ontology: DOID:3962]
Disease Ontology: DOID:3962
OMIM: 188470
Orphanet: ORPHA146


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1. Liu M, Bryant MS, Chen J, Lee S, Yaremko B, Lipari P, Malkowski M, Ferrari E, Nielsen L, Prioli N et al.. (1998) Antitumor activity of SCH 66336, an orally bioavailable tricyclic inhibitor of farnesyl protein transferase, in human tumor xenograft models and wap-ras transgenic mice. Cancer Res, 58 (21): 4947-56. [PMID:9810004]


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