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carboxyl ester lipase

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Target not currently curated in GtoImmuPdb

Target id: 2872

Nomenclature: carboxyl ester lipase

Family: 3.1.1.- Carboxylic Ester Hydrolases

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 753 9q34.13 CEL carboxyl ester lipase
Mouse - 599 2 19.38 cM Cel carboxyl ester lipase
Rat - 612 3p12 Cel carboxyl ester lipase
Previous and Unofficial Names Click here for help
BSSL | BSDL | MODY8 | bile salt-stimulated lipase | bile salt-dependent lipase
Database Links Click here for help
Alphafold
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 3.1.1.3
EC Number: 3.1.1.13

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 10f [PMID: 24556381] Small molecule or natural product Pig Inhibition 5.9 pIC50 1
pIC50 5.9 (IC50 1.33x10-6 M) [1]
compound 10l [PMID: 24556381] Small molecule or natural product Pig Inhibition 5.7 pIC50 1
pIC50 5.7 (IC50 1.98x10-6 M) [1]
Immuno Process Associations
Immuno Process:  Antigen presentation
GO Annotations:  Associated to 1 GO processes
GO:0048488 synaptic vesicle endocytosis IBA

References

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1. Muscia GC, Hautmann S, Buldain GY, Asís SE, Gütschow M. (2014) Synthesis and evaluation of 2-(1H-indol-3-yl)-4-phenylquinolines as inhibitors of cholesterol esterase. Bioorg Med Chem Lett, 24 (6): 1545-9. [PMID:24556381]

How to cite this page

3.1.1.- Carboxylic Ester Hydrolases: carboxyl ester lipase. Last modified on 13/08/2015. Accessed on 25/09/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2872.