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peptidyl arginine deiminase 1

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Immunopharmacology Ligand target has curated data in GtoImmuPdb

Target id: 2894

Nomenclature: peptidyl arginine deiminase 1

Family: Peptidyl arginine deiminases (PADI)

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 663 1p36.13 PADI1 peptidyl arginine deiminase 1
Mouse - 662 4 72.62 cM Padi1 peptidyl arginine deiminase, type I
Rat - 662 5q36 Padi1 peptidyl arginine deiminase 1
Previous and Unofficial Names Click here for help
HPAD10 | PDI1 | PDI | PAD1 | peptidyl arginine deiminase, type I | peptidyl arginine deiminase
Database Links Click here for help
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction Click here for help
EC Number: protein L-arginine + H2O <=> protein L-citrulline + NH3
Description Reaction Reference
protein L-arginine + H2O <=> protein L-citrulline + NH3

Download all structure-activity data for this target as a CSV file go icon to follow link

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
o-F-amidine Small molecule or natural product Primary target of this compound Click here for species-specific activity table Hs Irreversible inhibition 5.8 pIC50 1
pIC50 5.8 (IC50 1.4x10-6 M) [1]


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1. Causey CP, Jones JE, Slack JL, Kamei D, Jones LE, Subramanian V, Knuckley B, Ebrahimi P, Chumanevich AA, Luo Y et al.. (2011) The development of N-α-(2-carboxyl)benzoyl-N(5)-(2-fluoro-1-iminoethyl)-l-ornithine amide (o-F-amidine) and N-α-(2-carboxyl)benzoyl-N(5)-(2-chloro-1-iminoethyl)-l-ornithine amide (o-Cl-amidine) as second generation protein arginine deiminase (PAD) inhibitors. J Med Chem, 54 (19): 6919-35. [PMID:21882827]

How to cite this page Peptidyl arginine deiminases (PADI): peptidyl arginine deiminase 1. Last modified on 17/10/2018. Accessed on 05/07/2022. IUPHAR/BPS Guide to PHARMACOLOGY,