peptidyl arginine deiminase 1 | Peptidyl arginine deiminases (PADI) | IUPHAR/BPS Guide to PHARMACOLOGY

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peptidyl arginine deiminase 1

target has curated data in GtoImmuPdb

Target id: 2894

Nomenclature: peptidyl arginine deiminase 1

Family: Peptidyl arginine deiminases (PADI)

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 663 1p36.13 PADI1 peptidyl arginine deiminase 1
Mouse - 662 4 E1 Padi1 peptidyl arginine deiminase, type I
Rat - 662 5q36 Padi1 peptidyl arginine deiminase 1
Previous and Unofficial Names
HPAD10 | PDI1 | PDI | PAD1 | peptidyl arginine deiminase, type I | peptidyl arginine deiminase
Database Links
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number: protein L-arginine + H2O <=> protein L-citrulline + NH3
Description Reaction Reference
protein L-arginine + H2O <=> protein L-citrulline + NH3

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
o-F-amidine Hs Irreversible inhibition 5.8 pIC50 1
pIC50 5.8 (IC50 1.4x10-6 M) [1]


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1. Causey CP, Jones JE, Slack JL, Kamei D, Jones LE, Subramanian V, Knuckley B, Ebrahimi P, Chumanevich AA, Luo Y et al.. (2011) The development of N-α-(2-carboxyl)benzoyl-N(5)-(2-fluoro-1-iminoethyl)-l-ornithine amide (o-F-amidine) and N-α-(2-carboxyl)benzoyl-N(5)-(2-chloro-1-iminoethyl)-l-ornithine amide (o-Cl-amidine) as second generation protein arginine deiminase (PAD) inhibitors. J. Med. Chem., 54 (19): 6919-35. [PMID:21882827]

How to cite this page Peptidyl arginine deiminases (PADI): peptidyl arginine deiminase 1. Last modified on 17/10/2018. Accessed on 14/08/2020. IUPHAR/BPS Guide to PHARMACOLOGY,