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Zika virus genome polyprotein

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Target not currently curated in GtoImmuPdb

Target id: 2953

Nomenclature: Zika virus genome polyprotein

Systematic Nomenclature: Zika virus (strain Mr 766) (ZIKV) polyprotein

Family: Other viral proteins

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UniProtKB

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Allosteric Modulators
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
NSC157058 Small molecule or natural product ZIKV Inhibition 6.1 pIC50 1
pIC50 6.1 (IC50 8.2x10-7 M) [1]
General Comments
This polyprotein precursor is proteolytically processed inside the host cell to spawn a number of separate activities (see GO terms in UniProt entry), including enzymes that are important for viral replication. Several of these are being pursued as novel anti-viral drug targets.

References

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1. Shiryaev SA, Farhy C, Pinto A, Huang CT, Simonetti N, Ngono AE, Dewing A, Shresta S, Pinkerton AB, Cieplak P et al.. (2017) Characterization of the Zika virus two-component NS2B-NS3 protease and structure-assisted identification of allosteric small-molecule antagonists. Antiviral Res, 143: 218-229. [PMID:28461069]

How to cite this page

Other viral proteins: Zika virus genome polyprotein. Last modified on 31/03/2020. Accessed on 16/10/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2953.