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5-methyltetrahydrofolate-homocysteine methyltransferase

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Target not currently curated in GtoImmuPdb

Target id: 3099

Nomenclature: 5-methyltetrahydrofolate-homocysteine methyltransferase

Family: Methionine turnover

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1265 1q43 MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 1
Mouse - 1253 13 A1; 13 4.52 cM Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase
Rat - 1253 17q12.1 Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase
Previous and Unofficial Names Click here for help
cblG | cobalamin-dependent methionine synthase | vitamin-B12 dependent methionine synthase
Database Links Click here for help
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction Click here for help
EC Number: 5-methyltetrahydrofolate + L-homocysteine <=> tetrahydrofolate + L-methionine
General Comments
MTR catalyses the final step in methionine biosynthesis.


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1. Li YN, Gulati S, Baker PJ, Brody LC, Banerjee R, Kruger WD. (1996) Cloning, mapping and RNA analysis of the human methionine synthase gene. Hum. Mol. Genet., 5 (12): 1851-8. [PMID:8968735]

How to cite this page

Methionine turnover: 5-methyltetrahydrofolate-homocysteine methyltransferase. Last modified on 25/09/2019. Accessed on 21/10/2020. IUPHAR/BPS Guide to PHARMACOLOGY,