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Target not currently curated in GtoImmuPdb
Target id: 3099
Nomenclature: 5-methyltetrahydrofolate-homocysteine methyltransferase
Family: Methionine turnover
Gene and Protein Information ![]() |
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Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | - | 1265 | 1q43 | MTR | 5-methyltetrahydrofolate-homocysteine methyltransferase | 1 |
Mouse | - | 1253 | 13 4.52 cM | Mtr | 5-methyltetrahydrofolate-homocysteine methyltransferase | |
Rat | - | 1253 | 17q12.1 | Mtr | 5-methyltetrahydrofolate-homocysteine methyltransferase |
Previous and Unofficial Names ![]() |
cblG | cobalamin-dependent methionine synthase | vitamin-B12 dependent methionine synthase |
Database Links ![]() |
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Alphafold | Q99707 (Hs), A6H5Y3 (Mm), Q9Z2Q4 (Rn) |
BRENDA | 2.1.1.13 |
ChEMBL Target | CHEMBL2150844 (Hs), CHEMBL3188 (Mm) |
Ensembl Gene | ENSG00000116984 (Hs), ENSMUSG00000021311 (Mm), ENSRNOG00000017593 (Rn) |
Entrez Gene | 4548 (Hs), 238505 (Mm), 81522 (Rn) |
Human Protein Atlas | ENSG00000116984 (Hs) |
KEGG Enzyme | 2.1.1.13 |
KEGG Gene | hsa:4548 (Hs), mmu:238505 (Mm), rno:81522 (Rn) |
OMIM | 156570 (Hs) |
Pharos | Q99707 (Hs) |
RefSeq Nucleotide | NM_000254 (Hs), NM_001081128 (Mm), NM_030864 (Rn) |
RefSeq Protein | NP_000245 (Hs), NP_001074597 (Mm), NP_110491 (Rn) |
UniProtKB | Q99707 (Hs), A6H5Y3 (Mm), Q9Z2Q4 (Rn) |
Wikipedia | MTR (Hs) |
Enzyme Reaction ![]() |
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General Comments |
MTR catalyses the final step in methionine biosynthesis. |
Methionine turnover: 5-methyltetrahydrofolate-homocysteine methyltransferase. Last modified on 25/09/2019. Accessed on 07/02/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=3099.