5-methyltetrahydrofolate-homocysteine methyltransferase | Methionine turnover | IUPHAR/BPS Guide to PHARMACOLOGY

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5-methyltetrahydrofolate-homocysteine methyltransferase

Target not currently curated in GtoImmuPdb

Target id: 3099

Nomenclature: 5-methyltetrahydrofolate-homocysteine methyltransferase

Family: Methionine turnover

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1265 1q43 MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 1
Mouse - 1253 13 A1; 13 4.52 cM Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase
Rat - 1253 17q12.1 Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase
Previous and Unofficial Names
cblG | cobalamin-dependent methionine synthase | vitamin-B12 dependent methionine synthase
Database Links
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number: 5-methyltetrahydrofolate + L-homocysteine <=> tetrahydrofolate + L-methionine
General Comments
MTR catalyses the final step in methionine biosynthesis.


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1. Li YN, Gulati S, Baker PJ, Brody LC, Banerjee R, Kruger WD. (1996) Cloning, mapping and RNA analysis of the human methionine synthase gene. Hum. Mol. Genet., 5 (12): 1851-8. [PMID:8968735]

How to cite this page

Methionine turnover: 5-methyltetrahydrofolate-homocysteine methyltransferase. Last modified on 25/09/2019. Accessed on 14/08/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=3099.