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Acylated lysine reader proteins

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Targets

3183
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ENL (MLLT1 super elongation complex subunit) Show summary »

Target Id 3183
Nomenclature MLLT1 super elongation complex subunit
Common abbreviation ENL
Previous and unofficial names MLLT1, super elongation complex subunit | MLLT1 | ENL | LTG19 | myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1 | YEATS1
Genes MLLT1 (Hs), Mllt1 (Mm), Mllt1 (Rn)
Ensembl ID ENSG00000130382 (Hs), ENSMUSG00000024212 (Mm), ENSRNOG00000048736 (Rn)
UniProtKB AC Q03111 (Hs)
Inhibitors
SR-0813 pKd 7.5 [1]
Comment ENL is a chromatin reader that contains a YEATS domain that recognises acylated lysine side chains within the amino-terminal tails of histone H3. It acts as a co-activator within the transcriptional super elongation complex (SEC). ENL has been identified as a driving factor in an aggressive subset of acute leukemia with oncogenic rearrangements of the multiple lineage leukemia (MLL) gene. This suggests that inhibiting ENL's interaction with acylated lysine marks could be leveraged as a therapeutic intervention in these cancers.

References

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How to cite this family page

Database page citation:

Acylated lysine reader proteins. Accessed on 27/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1067.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Buneman OP, Faccenda E, Harding SD, Spedding M, Cidlowski JA, Fabbro D, Davenport AP, Striessnig J, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Introduction and Other Protein Targets. Br J Pharmacol. 180 Suppl 2:S1-22.