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chitinase 1

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Target not currently curated in GtoImmuPdb

Target id: 3187

Nomenclature: chitinase 1

Family: Chitinases

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 466 1q32.1 CHIT1 chitinase 1
Mouse - 464 1 E4 Chit1 chitinase 1 (chitotriosidase)
Rat - 464 13q13 Chit1 chitinase 1
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ChEMBL Target
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Selected 3D Structures Click here for help
Image of receptor 3D structure from RCSB PDB
Description:  Crystal structure of human chitotriosidase-1 (hCHIT) catalytic domain in complex with compound OATD-01 (GLPG4716)
PDB Id:  6ZE8
Ligand:  GLPG4716
Resolution:  1.5Å
Species:  Human
References:  1

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
GLPG4716 Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 7.6 pIC50 1
pIC50 7.6 (IC50 2.3x10-8 M) [1]
GLPG4716 Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Mm Inhibition 7.6 pIC50 1
pIC50 7.6 (IC50 2.8x10-8 M) [1]
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References

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1. Koralewski R, Dymek B, Mazur M, Sklepkiewicz P, Olejniczak S, Czestkowski W, Matyszewski K, Andryianau G, Niedziejko P, Kowalski M et al.. (2020) Discovery of OATD-01, a First-in-Class Chitinase Inhibitor as Potential New Therapeutics for Idiopathic Pulmonary Fibrosis. J Med Chem, 63 (24): 15527-15540. [PMID:33078933]

How to cite this page

Chitinases: chitinase 1. Last modified on 16/07/2021. Accessed on 21/10/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=3187.