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STIP1 homology and U-box containing protein 1

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Immunopharmacology Ligand target has curated data in GtoImmuPdb

Target id: 3202

Nomenclature: STIP1 homology and U-box containing protein 1

Family: E3 ubiquitin ligase components

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 303 16p13.3 STUB1 STIP1 homology and U-box containing protein 1
Mouse - 304 17 12.93 cM Stub1 STIP1 homology and U-Box containing protein 1
Rat - 304 10q12 Stub1 STIP1 homology and U-box containing protein 1
Gene and Protein Information Comments
Alternative splicing of the human gene results in multiple transcript variants.
Previous and Unofficial Names Click here for help
E3 ubiquitin-protein ligase CHIP | carboxy terminus of the Hsp70-interacting protein (CHIP) | UBOX1 | NY-CO-7
Database Links Click here for help
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction Click here for help
EC Number:

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Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
peptide 22d Small molecule or natural product Hs Binding 6.3 pKd 3
pKd 6.3 (Kd 5.21x10-7 M) [3]
Immunopharmacology Comments
STUB1 acts as a pivotal negative regulator of interferon-γ-mediated immune functions, via destabilisation of the ligand-receptor complex [1-2].
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Spinocerebellar ataxia 48: SCA48, autosomal dominant
Description: An autosomal dominant neurodegenerative disorder that is characterised by the onset of gait ataxia and/or cognitive-affective symptoms in midadulthood. Caused by heterozygous mutations in the STUB1 gene concurrently with an expanded repeat allele of the TBP gene.
OMIM: 618093
Disease:  Spinocerebellar ataxia, autosomal recessive 16; SCAR16
Description: SCAR16 is caused by homozygous or compound heterozygous mutation in the STUB1 gene. It is a progressive neurologic disorder that is characterised by truncal and limb ataxia rhat cause gait instability and which is associated with cerebellar atrophy. Onset is generally in teenagers. There are some overlapping features with SCA48.
OMIM: 615768


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1. Apriamashvili G, Vredevoogd DW, Krijgsman O, Bleijerveld OB, Ligtenberg MA, de Bruijn B, Boshuizen J, Traets JJH, D'Empaire Altimari D, van Vliet A et al.. (2022) Ubiquitin ligase STUB1 destabilizes IFNγ-receptor complex to suppress tumor IFNγ signaling. Nat Commun, 13 (1): 1923. [PMID:35395848]

2. Ebner P, Versteeg GA, Ikeda F. (2017) Ubiquitin enzymes in the regulation of immune responses. Crit Rev Biochem Mol Biol, 52 (4): 425-460. [PMID:28524749]

3. Ng S, Brueckner AC, Bahmanjah S, Deng Q, Johnston JM, Ge L, Duggal R, Habulihaz B, Barlock B, Ha S et al.. (2022) Discovery and Structure-Based Design of Macrocyclic Peptides Targeting STUB1. J Med Chem, [Epub ahead of print]. [PMID:35853179]

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