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GABAA receptor β1 subunit

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Target not currently curated in GtoImmuPdb

Target id: 410

Nomenclature: GABAA receptor β1 subunit

Family: GABAA receptors

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 4 474 4p12 GABRB1 gamma-aminobutyric acid type A receptor subunit beta1 2-3
Mouse 4 474 5 C3.2 Gabrb1 gamma-aminobutyric acid (GABA) A receptor, subunit beta 1 1
Rat 4 474 14p11 Gabrb1 gamma-aminobutyric acid type A receptor subunit beta1 4
Previous and Unofficial Names Click here for help
gamma-aminobutyric acid receptor subunit beta-1 | Gabrb-1 | gamma-aminobutyric acid (GABA) A receptor, beta 1 | gamma-aminobutyric acid (GABA) A receptor, subunit beta 1 | gamma-aminobutyric acid (GABA) A receptor | gamma-aminobutyric acid type A receptor beta1 subunit | gamma-aminobutyric acid type A receptor beta 1 subunit
Database Links Click here for help
CATH/Gene3D
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Natural/Endogenous Ligands Click here for help
GABA

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Channel Blockers
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Use-dependent Value Parameter Concentration range (M) Voltage-dependent (mV) Reference
picrotoxin Small molecule or natural product Click here for species-specific activity table Hs - no - - - no

Not voltage dependent
TBPS Small molecule or natural product Click here for species-specific activity table Hs - no - - - no

Not voltage dependent

References

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1. Kamatchi GL, Kofuji P, Wang JB, Fernando JC, Liu Z, Mathura JR, Burt DR. (1995) GABAA receptor beta 1, beta 2, and beta 3 subunits: comparisons in DBA/2J and C57BL/6J mice. Biochim. Biophys. Acta, 1261 (1): 134-42. [PMID:7893750]

2. Kirkness EF, Kusiak JW, Fleming JT, Menninger J, Gocayne JD, Ward DC, Venter JC. (1991) Isolation, characterization, and localization of human genomic DNA encoding the beta 1 subunit of the GABAA receptor (GABRB1). Genomics, 10 (4): 985-95. [PMID:1655634]

3. Schofield PR, Pritchett DB, Sontheimer H, Kettenmann H, Seeburg PH. (1989) Sequence and expression of human GABAA receptor alpha 1 and beta 1 subunits. FEBS Lett., 244 (2): 361-4. [PMID:2465923]

4. Ymer S, Schofield PR, Draguhn A, Werner P, Köhler M, Seeburg PH. (1989) GABAA receptor beta subunit heterogeneity: functional expression of cloned cDNAs. EMBO J., 8 (6): 1665-70. [PMID:2548852]

Contributors

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