Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	3	632	Xq28	GABRQ	gamma-aminobutyric acid type A receptor subunit theta	1
Mouse	3	638	X A6	Gabrq	gamma-aminobutyric acid (GABA) A receptor, subunit theta	3
Rat	4	635	Xq37	Gabrq	gamma-aminobutyric acid type A receptor subunit theta	3

Previous and Unofficial Names

gamma-aminobutyric acid receptor subunit theta | gamma-aminobutyric acid (GABA) A receptor, theta | gamma-aminobutyric acid (GABA) A receptor, subunit theta | gamma-aminobutyric acid (GABA) A receptor | gamma-aminobutyric acid type A receptor theta subunit

Database Links
Alphafold	Q9UN88 (Hs), Q9JLF1 (Mm)
CATH/Gene3D	2.70.170.10
ChEMBL Target	CHEMBL3885575 (Hs), CHEMBL2094133 (Mm)
DrugBank Target	Q9UN88 (Hs), Q9UN88 (Hs)
Ensembl Gene	ENSG00000268089 (Hs), ENSMUSG00000031344 (Mm), ENSRNOG00000053402 (Rn)
Entrez Gene	55879 (Hs), 57249 (Mm), 65187 (Rn)
Human Protein Atlas	ENSG00000268089 (Hs)
KEGG Gene	hsa:55879 (Hs), mmu:57249 (Mm), rno:65187 (Rn)
OMIM	300349 (Hs)
Pharos	Q9UN88 (Hs)
RefSeq Nucleotide	NM_018558 (Hs), NM_020488 (Mm), NM_031733 (Rn)
RefSeq Protein	NP_061028 (Hs), NP_065234 (Mm), NP_113921 (Rn)
UniProtKB	Q9UN88 (Hs), Q9JLF1 (Mm)
Wikipedia	GABRQ (Hs)

Natural/Endogenous Ligands
GABA

Download all structure-activity data for this target as a CSV file

Channel Blockers
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Use-dependent Value Parameter Concentration range (M) Voltage-dependent (mV) Reference picrotoxin Hs - no - - - no ⤷ Not voltage dependent TBPS Hs - no - - - no ⤷ Not voltage dependent

Tissue Distribution
Substantia nigra pars compacta, locus coeruleus Species:  Human Technique:  In situ hybridization and immunohistochemistry References:  1
Locus coeruleus, centromedial thalamic region, hypothalamus (dorsomedial and ventromedial regions) Species:  Rat Technique:  In situ hybridisation References:  3
Septum (ventral and intermediate nucleus), bed nuclei and the stria terminalis, amygdala (medial and central nuclei), dentate gyrus, preoptic areas, hypothalamus, thalamus, lateral geniculate nucleus, raphe nuclei, locus coeruleus Species:  Rat Technique:  In situ hybridisation References:  2
Cerebral cortex (cingulate and piriform regions), olfactory tract, nucleus accumbens, hypothalamus (anterior and mammiliary body), amygdala, hippocampus, substantia nigra, pineal gland, pons, dorsal raphe, central grey Species:  Monkey Technique:  In situ hybridisation References:  1
Hypothalamus, cortical pyramidal neurones, substantia nigra pars compacta and associated neurites of the pars reticulata, ventral and lateral tegmental areas, locus coeruleus, recticular pontine nuclei, dorsal raphe Species:  Monkey Technique:  Immunohistochemistry References:  1