GABA<sub>A</sub> receptor θ subunit | GABA<sub>A</sub> receptors | IUPHAR/BPS Guide to PHARMACOLOGY

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GABAA receptor θ subunit

Target not currently curated in GtoImmuPdb

Target id: 418

Nomenclature: GABAA receptor θ subunit

Family: GABAA receptors

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 4 632 Xq28 GABRQ gamma-aminobutyric acid type A receptor subunit theta 1
Mouse 4 638 X A6 Gabrq gamma-aminobutyric acid (GABA) A receptor, subunit theta 3
Rat 4 635 Xq37 Gabrq gamma-aminobutyric acid type A receptor subunit theta 3
Previous and Unofficial Names
gamma-aminobutyric acid receptor subunit theta | gamma-aminobutyric acid (GABA) A receptor, theta | gamma-aminobutyric acid (GABA) A receptor, subunit theta | gamma-aminobutyric acid (GABA) A receptor | gamma-aminobutyric acid type A receptor theta subunit
Database Links
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
RefSeq Nucleotide
RefSeq Protein
Natural/Endogenous Ligands

Download all structure-activity data for this target as a CSV file

Channel Blockers
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Use-dependent Value Parameter Concentration range (M) Voltage-dependent (mV) Reference
picrotoxin Hs - no - - - no

Not voltage dependent
TBPS Hs - no - - - no

Not voltage dependent
Tissue Distribution
Substantia nigra pars compacta, locus coeruleus
Species:  Human
Technique:  In situ hybridization and immunohistochemistry
References:  1
Locus coeruleus, centromedial thalamic region, hypothalamus (dorsomedial and ventromedial regions)
Species:  Rat
Technique:  In situ hybridisation
References:  3
Septum (ventral and intermediate nucleus), bed nuclei and the stria terminalis, amygdala (medial and central nuclei), dentate gyrus, preoptic areas, hypothalamus, thalamus, lateral geniculate nucleus, raphe nuclei, locus coeruleus
Species:  Rat
Technique:  In situ hybridisation
References:  2
Cerebral cortex (cingulate and piriform regions), olfactory tract, nucleus accumbens, hypothalamus (anterior and mammiliary body), amygdala, hippocampus, substantia nigra, pineal gland, pons, dorsal raphe, central grey
Species:  Monkey
Technique:  In situ hybridisation
References:  1
Hypothalamus, cortical pyramidal neurones, substantia nigra pars compacta and associated neurites of the pars reticulata, ventral and lateral tegmental areas, locus coeruleus, recticular pontine nuclei, dorsal raphe
Species:  Monkey
Technique:  Immunohistochemistry
References:  1


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1. Bonnert TP, McKernan RM, Farrar S, le Bourdellès B, Heavens RP, Smith DW, Hewson L, Rigby MR, Sirinathsinghji DJ, Brown N, Wafford KA, Whiting PJ. (1999) theta, a novel gamma-aminobutyric acid type A receptor subunit. Proc. Natl. Acad. Sci. U.S.A., 96 (17): 9891-6. [PMID:10449790]

2. Moragues N, Ciofi P, Tramu G, Garret M. (2002) Localisation of GABA(A) receptor epsilon-subunit in cholinergic and aminergic neurones and evidence for co-distribution with the theta-subunit in rat brain. Neuroscience, 111 (3): 657-69. [PMID:12031352]

3. Sinkkonen ST, Hanna MC, Kirkness EF, Korpi ER. (2000) GABA(A) receptor epsilon and theta subunits display unusual structural variation between species and are enriched in the rat locus ceruleus. J. Neurosci., 20 (10): 3588-95. [PMID:10804200]


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