Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	4	473	6q13-q16.3	GABRR1	gamma-aminobutyric acid type A receptor rho1 subunit	2
Mouse	4	474	4 A5	Gabrr1	gamma-aminobutyric acid (GABA) C receptor, subunit rho 1	4
Rat	4	474	5q21	Gabrr1	gamma-aminobutyric acid type A receptor rho 1 subunit	1

Previous and Unofficial Names

GABA(A) receptor subunit rho-1 | gamma-aminobutyric acid (GABA) A receptor, rho 1 | gamma-aminobutyric acid (GABA) C receptor, subunit rho 1 | gamma-aminobutyric acid (GABA) C receptor

Database Links
CATH/Gene3D	2.70.170.10
ChEMBL Target	CHEMBL3561 (Hs)
DrugBank Target	P24046 (Hs)
Ensembl Gene	ENSG00000146276 (Hs), ENSMUSG00000028280 (Mm), ENSRNOG00000007603 (Rn)
Entrez Gene	2569 (Hs), 14408 (Mm), 29694 (Rn)
Human Protein Atlas	ENSG00000146276 (Hs)
KEGG Gene	hsa:2569 (Hs), mmu:14408 (Mm), rno:29694 (Rn)
OMIM	137161 (Hs)
RefSeq Nucleotide	NM_002042 (Hs), NM_008075 (Mm), NM_017291 (Rn)
RefSeq Protein	NP_002033 (Hs), NP_032101 (Mm), NP_058987 (Rn)
UniProtKB	P24046 (Hs), P56475 (Mm), P50572 (Rn)
Wikipedia	GABRR1 (Hs)

Natural/Endogenous Ligands
GABA

Download all structure-activity data for this target as a CSV file

Agonists
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference CACA Rn Agonist 4.1 pEC50 3 ⤷ pEC50 4.1 (EC50 7.4x10-5 M) [3] (±)-cis-2-CAMP Hs Full agonist - - ⤷ [Binds to: GABA site] 5-Me-IAA Hs Full agonist - - ⤷ [Binds to: GABA site] isoguvacine Hs Partial agonist - - ⤷ [Binds to: GABA site] muscimol Hs Partial agonist - - ⤷ [Binds to: GABA site]
View species-specific agonist tables

Antagonists
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference cis-3-ACPBPA Hs Antagonist - - ⤷ [Binds to: GABA site] trans-3-ACPBPA Hs Antagonist - - ⤷ [Binds to: GABA site] aza-THIP Hs Antagonist - - ⤷ [Binds to: GABA site] isonipecotic acid Hs Antagonist - - ⤷ [Binds to: GABA site] piperidine-4-sulphonic acid Hs Antagonist - - ⤷ [Binds to: GABA site] gaboxadol Hs Antagonist - - ⤷ [Binds to: GABA site] TPMPA Hs Antagonist - - ⤷ [Binds to: GABA site]

Channel Blockers
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Use-dependent Value Parameter Concentration range (M) Voltage-dependent (mV) Reference picrotoxin Hs - no - - - no ⤷ Not voltage dependent TBPS Hs - no - - - no ⤷ Not voltage dependent