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GABAA receptor ρ3 subunit

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Target not currently curated in GtoImmuPdb

Target id: 422

Nomenclature: GABAA receptor ρ3 subunit

Family: GABAA receptors

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 4 467 3q11.2 GABRR3 gamma-aminobutyric acid type A receptor subunit rho3 1
Mouse 4 464 16 C1.3 Gabrr3 gamma-aminobutyric acid (GABA) receptor, rho 3 3
Rat 4 464 11q12 Gabrr3 gamma-aminobutyric acid type A receptor subunit rho3 2
Previous and Unofficial Names Click here for help
GABA(A) receptor subunit rho-3 | gamma-aminobutyric acid (GABA) A receptor, rho 3 | gamma-aminobutyric acid (GABA) A receptor, rho 3 (gene/pseudogene) | gamma-aminobutyric acid (GABA) A receptor | gamma-aminobutyric acid (GABA) receptor | gamma-aminobutyric acid type A receptor rho3 subunit (gene/pseudogene) | gamma-aminobutyric acid type A receptor subunit rho3 (gene/pseudogene) | gamma-aminobutyric acid type A receptor rho3 subunit
Database Links Click here for help
CATH/Gene3D
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Natural/Endogenous Ligands Click here for help
GABA

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Agonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
(±)-cis-2-CAMP Small molecule or natural product Click here for species-specific activity table Hs Full agonist - -
[Binds to: GABA site]
5-Me-IAA Small molecule or natural product Click here for species-specific activity table Hs Full agonist - -
[Binds to: GABA site]
isoguvacine Small molecule or natural product Click here for species-specific activity table Hs Partial agonist - -
[Binds to: GABA site]
muscimol Small molecule or natural product Click here for species-specific activity table Hs Partial agonist - -
[Binds to: GABA site]
Antagonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
cis-3-ACPBPA Small molecule or natural product Click here for species-specific activity table Hs Antagonist - -
[Binds to: GABA site]
trans-3-ACPBPA Small molecule or natural product Click here for species-specific activity table Hs Antagonist - -
[Binds to: GABA site]
aza-THIP Small molecule or natural product Click here for species-specific activity table Hs Antagonist - -
[Binds to: GABA site]
isonipecotic acid Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Antagonist - -
[Binds to: GABA site]
piperidine-4-sulphonic acid Small molecule or natural product Click here for species-specific activity table Hs Antagonist - -
[Binds to: GABA site]
gaboxadol Small molecule or natural product Click here for species-specific activity table Hs Antagonist - -
[Binds to: GABA site]
TPMPA Small molecule or natural product Click here for species-specific activity table Hs Antagonist - -
[Binds to: GABA site]
Channel Blockers
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Use-dependent Value Parameter Concentration range (M) Voltage-dependent (mV) Reference
picrotoxin Small molecule or natural product Click here for species-specific activity table Hs - no - - - no

Not voltage dependent
TBPS Small molecule or natural product Click here for species-specific activity table Hs - no - - - no

Not voltage dependent

References

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1. Bailey ME, Albrecht BE, Johnson KJ, Darlison MG. (1999) Genetic linkage and radiation hybrid mapping of the three human GABA(C) receptor rho subunit genes: GABRR1, GABRR2 and GABRR3. Biochim. Biophys. Acta, 1447 (2-3): 307-12. [PMID:10542332]

2. Ogurusu T, Shingai R. (1996) Cloning of a putative gamma-aminobutyric acid (GABA) receptor subunit rho 3 cDNA. Biochim. Biophys. Acta, 1305 (1-2): 15-8. [PMID:8605242]

3. Rose M, Dütting E, Schröder N, Sticht H, Brandstätter JH, Enz R. (2008) PNUTS forms a trimeric protein complex with GABA(C) receptors and protein phosphatase 1. Mol. Cell. Neurosci., 37 (4): 808-19. [PMID:18325784]

Contributors

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