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GABAA receptor ρ3 subunit

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Target not currently curated in GtoImmuPdb

Target id: 422

Nomenclature: GABAA receptor ρ3 subunit

Family: GABAA receptors

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 4 467 3q11.2 GABRR3 gamma-aminobutyric acid type A receptor subunit rho3 1
Mouse 4 464 16 C1.3 Gabrr3 gamma-aminobutyric acid type A receptor subunit rho 3 4
Rat 4 464 11q12 Gabrr3 gamma-aminobutyric acid type A receptor subunit rho3 3
Previous and Unofficial Names Click here for help
GABA(A) receptor subunit rho-3 | gamma-aminobutyric acid (GABA) A receptor, rho 3 | gamma-aminobutyric acid (GABA) A receptor, rho 3 (gene/pseudogene) | gamma-aminobutyric acid (GABA) A receptor | gamma-aminobutyric acid (GABA) receptor | gamma-aminobutyric acid type A receptor rho3 subunit (gene/pseudogene) | gamma-aminobutyric acid type A receptor subunit rho3 (gene/pseudogene) | gamma-aminobutyric acid type A receptor rho3 subunit
Database Links Click here for help
Alphafold A8MPY1 (Hs), P50573 (Rn)
CATH/Gene3D 2.70.170.10
ChEMBL Target CHEMBL2109242 (Hs)
DrugBank Target A8MPY1 (Hs)
Ensembl Gene ENSG00000183185 (Hs), ENSMUSG00000074991 (Mm), ENSRNOG00000001679 (Rn)
Entrez Gene 200959 (Hs), 328699 (Mm), 192258 (Rn)
Human Protein Atlas ENSG00000183185 (Hs)
KEGG Gene hsa:200959 (Hs), mmu:328699 (Mm), rno:192258 (Rn)
Pharos A8MPY1 (Hs)
RefSeq Nucleotide NM_001105580 (Hs), NM_001081190 (Mm), NM_138897 (Rn)
RefSeq Protein NP_001099050 (Hs), NP_001074659 (Mm), NP_620252 (Rn)
UniProtKB A8MPY1 (Hs), P50573 (Rn)
Wikipedia GABRR3 (Hs)
Natural/Endogenous Ligands Click here for help
GABA

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Agonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
(±)-cis-2-CAMP Small molecule or natural product Click here for species-specific activity table Hs Full agonist - -
⤷ [Binds to: GABA site]
5-Me-IAA Small molecule or natural product Click here for species-specific activity table Hs Full agonist - -
⤷ [Binds to: GABA site]
isoguvacine Small molecule or natural product Click here for species-specific activity table Hs Partial agonist - -
⤷ [Binds to: GABA site]
muscimol Small molecule or natural product Click here for species-specific activity table Hs Partial agonist - -
⤷ [Binds to: GABA site]
Antagonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
cis-3-ACPBPA Small molecule or natural product Click here for species-specific activity table Hs Antagonist - -
⤷ [Binds to: GABA site]
trans-3-ACPBPA Small molecule or natural product Click here for species-specific activity table Hs Antagonist - -
⤷ [Binds to: GABA site]
aza-THIP Small molecule or natural product Click here for species-specific activity table Hs Antagonist - -
⤷ [Binds to: GABA site]
isonipecotic acid Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Antagonist - -
⤷ [Binds to: GABA site]
piperidine-4-sulphonic acid Small molecule or natural product Click here for species-specific activity table Hs Antagonist - -
⤷ [Binds to: GABA site]
gaboxadol Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Antagonist - - 2
⤷ [Binds to: GABA site] [2]
TPMPA Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Antagonist - -
⤷ [Binds to: GABA site]
Channel Blockers
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Use-dependent Value Parameter Concentration range (M) Voltage-dependent (mV) Reference
picrotoxin Small molecule or natural product Click here for species-specific activity table Hs - no - - - no
⤷
Not voltage dependent
TBPS Small molecule or natural product Click here for species-specific activity table Hs - no - - - no
⤷
Not voltage dependent

References

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1. Bailey ME, Albrecht BE, Johnson KJ, Darlison MG. (1999) Genetic linkage and radiation hybrid mapping of the three human GABA(C) receptor rho subunit genes: GABRR1, GABRR2 and GABRR3. Biochim Biophys Acta, 1447 (2-3): 307-12. [PMID:10542332]

2. Krehan D, Frølund B, Ebert B, Nielsen B, Krogsgaard-Larsen P, Johnston GA, Chebib M. (2003) Aza-THIP and related analogues of THIP as GABA C antagonists. Bioorg Med Chem, 11 (23): 4891-6. [PMID:14604650]

3. Ogurusu T, Shingai R. (1996) Cloning of a putative gamma-aminobutyric acid (GABA) receptor subunit rho 3 cDNA. Biochim Biophys Acta, 1305 (1-2): 15-8. [PMID:8605242]

4. Rose M, Dütting E, Schröder N, Sticht H, Brandstätter JH, Enz R. (2008) PNUTS forms a trimeric protein complex with GABA(C) receptors and protein phosphatase 1. Mol Cell Neurosci, 37 (4): 808-19. [PMID:18325784]

Contributors

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