Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	4	467	3q11.2	GABRR3	gamma-aminobutyric acid type A receptor subunit rho3 (gene/pseudogene)	1
Mouse	4	464	16 C1.3	Gabrr3	gamma-aminobutyric acid (GABA) receptor	3
Rat	4	464	11q12	Gabrr3	gamma-aminobutyric acid type A receptor rho3 subunit	2

Previous and Unofficial Names

GABA(A) receptor subunit rho-3 | gamma-aminobutyric acid (GABA) A receptor, rho 3 | gamma-aminobutyric acid (GABA) A receptor, rho 3 (gene/pseudogene) | gamma-aminobutyric acid (GABA) A receptor | gamma-aminobutyric acid (GABA) receptor | gamma-aminobutyric acid type A receptor rho3 subunit (gene/pseudogene)

Database Links
CATH/Gene3D	2.70.170.10
ChEMBL Target	CHEMBL2109242 (Hs)
DrugBank Target	A8MPY1 (Hs)
Ensembl Gene	ENSG00000183185 (Hs), ENSMUSG00000074991 (Mm), ENSRNOG00000001679 (Rn)
Entrez Gene	200959 (Hs), 328699 (Mm), 192258 (Rn)
Human Protein Atlas	ENSG00000183185 (Hs)
KEGG Gene	hsa:200959 (Hs), mmu:328699 (Mm), rno:192258 (Rn)
Pharos	A8MPY1 (Hs)
RefSeq Nucleotide	NM_001105580 (Hs), NM_001081190 (Mm), NM_138897 (Rn)
RefSeq Protein	NP_001099050 (Hs), NP_001074659 (Mm), NP_620252 (Rn)
UniProtKB	A8MPY1 (Hs), P50573 (Rn)
Wikipedia	GABRR3 (Hs)

Natural/Endogenous Ligands
GABA

Download all structure-activity data for this target as a CSV file

Agonists
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference (±)-cis-2-CAMP Hs Full agonist - - ⤷ [Binds to: GABA site] 5-Me-IAA Hs Full agonist - - ⤷ [Binds to: GABA site] isoguvacine Hs Partial agonist - - ⤷ [Binds to: GABA site] muscimol Hs Partial agonist - - ⤷ [Binds to: GABA site]

Antagonists
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference cis-3-ACPBPA Hs Antagonist - - ⤷ [Binds to: GABA site] trans-3-ACPBPA Hs Antagonist - - ⤷ [Binds to: GABA site] aza-THIP Hs Antagonist - - ⤷ [Binds to: GABA site] isonipecotic acid Hs Antagonist - - ⤷ [Binds to: GABA site] piperidine-4-sulphonic acid Hs Antagonist - - ⤷ [Binds to: GABA site] gaboxadol Hs Antagonist - - ⤷ [Binds to: GABA site] TPMPA Hs Antagonist - - ⤷ [Binds to: GABA site]

Channel Blockers
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Use-dependent Value Parameter Concentration range (M) Voltage-dependent (mV) Reference picrotoxin Hs - no - - - no ⤷ Not voltage dependent TBPS Hs - no - - - no ⤷ Not voltage dependent