<i>GPR107</i> | Other 7TM proteins | IUPHAR/BPS Guide to PHARMACOLOGY

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Target not currently curated in GtoImmuPdb

Target id: 651

Nomenclature: GPR107

Family: Other 7TM proteins

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

This receptor has a proposed ligand; see the Latest Pairings page for more information.

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 600 9q34.11 GPR107 G protein-coupled receptor 107
Mouse 7 551 2 B Gpr107 G protein-coupled receptor 107
Rat 7 551 3p12 Gpr107 G protein-coupled receptor 107
Previous and Unofficial Names
LUSTR1 | GCDRP | Lung seven transmembrane receptor 1
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
RefSeq Nucleotide
RefSeq Protein
Natural/Endogenous Ligands
neuronostatin {Sp: Human, Pig}
Comments: Proposed ligand, single publication
Immuno Process Associations
Immuno Process:  Antigen presentation
GO Annotations:  Associated to 1 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0072583 clathrin-dependent endocytosis IEA
General Comments
GPR107 is a member of the LUSTR family of proteins found in both plants and animals, having similar topology to G protein-coupled receptors [1].

Neuronostatin, an endogenous peptide from the somatostatin precursor, has been demonstated to be a ligand for GPR107 in one publication [2].


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1. Edgar AJ. (2007) Human GPR107 and murine Gpr108 are members of the LUSTR family of proteins found in both plants and animals, having similar topology to G-protein coupled receptors. DNA Seq., 18 (3): 235-41. [PMID:17454009]

2. Yosten GL, Redlinger LJ, Samson WK. (2012) Evidence for an interaction of neuronostatin with the orphan G protein-coupled receptor, GPR107. Am. J. Physiol. Regul. Integr. Comp. Physiol., 303 (9): R941-9. [PMID:22933024]


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How to cite this page

Tom I. Bonner.
Other 7TM proteins: GPR107. Last modified on 13/02/2017. Accessed on 06/04/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=651.