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Target not currently curated in GtoImmuPdb
Target id: 651
Nomenclature: GPR107
Family: Other non-GPCR 7TM proteins
This receptor has a proposed ligand; see the Latest Pairings page for more information.
Gene and Protein Information  |
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| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | 7 | 600 | 9q34.11 | GPR107 | G protein-coupled receptor 107 | |
| Mouse | 7 | 551 | 2 B | Gpr107 | G protein-coupled receptor 107 | |
| Rat | 7 | 551 | 3p12 | Gpr107 | G protein-coupled receptor 107 | |
| Previous and Unofficial Names |
| LUSTR1 | GCDRP | Lung seven transmembrane receptor 1 |
| Database Links |
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| Alphafold | Q5VW38 (Hs), Q8BUV8 (Mm), D3ZWZ9 (Rn) |
| ChEMBL Target | CHEMBL4630835 (Hs) |
| Ensembl Gene | ENSG00000148358 (Hs), ENSMUSG00000000194 (Mm), ENSRNOG00000023589 (Rn) |
| Entrez Gene | 57720 (Hs), 277463 (Mm), 311857 (Rn) |
| Human Protein Atlas | ENSG00000148358 (Hs) |
| KEGG Gene | hsa:57720 (Hs), mmu:277463 (Mm), rno:311857 (Rn) |
| Pharos | Q5VW38 (Hs) |
| RefSeq Nucleotide | NM_001136558 (Hs), NM_020960 (Hs), NM_001136557 (Hs), NM_178760 (Mm), NM_001107828 (Rn) |
| RefSeq Protein | NP_001130030 (Hs), NP_001130029 (Hs), NP_066011 (Hs), NP_848875 (Mm), NP_001101298 (Rn) |
| UniProtKB | Q5VW38 (Hs), Q8BUV8 (Mm), D3ZWZ9 (Rn) |
| Wikipedia | GPR107 (Hs) |
| Natural/Endogenous Ligands |
| neuronostatin {Sp: Human, Pig} |
| Comments: Proposed ligand, single publication |
| Immuno Process Associations | |||||||||
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| General Comments |
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GPR107 is a member of the LUSTR family of proteins found in both plants and animals, having similar topology to G protein-coupled receptors [1]. Neuronostatin, an endogenous peptide from the somatostatin precursor, has been demonstated to be a ligand for GPR107 in one publication [2]. |
1. Edgar AJ. (2007) Human GPR107 and murine Gpr108 are members of the LUSTR family of proteins found in both plants and animals, having similar topology to G-protein coupled receptors. DNA Seq, 18 (3): 235-41. [PMID:17454009]
2. Yosten GL, Redlinger LJ, Samson WK. (2012) Evidence for an interaction of neuronostatin with the orphan G protein-coupled receptor, GPR107. Am J Physiol Regul Integr Comp Physiol, 303 (9): R941-9. [PMID:22933024]
