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Your search for repurposing returned 46 results

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Ligand: lebrikizumab
Clinical use: repurposed as a potential asthma treatment . The antibody entered Phase 2 trial for idiopathic pulmonary
Immuno Disease Ligand Comment: Repurposed clinical candidate for IPF (Phase 2).
Immuno Disease Ligand Comment: Repurposed clinical candidate for asthma (Phase 3).
Ligand: metformin
Comments: this could ultimately lead to metformin being repurposed for indications other than type 2 diabetes.
Immuno Ligand Comments: found to be effective, this could ultimately lead to metformin being repurposed for inflammatory indications .
Disease: Asthma
Ligand association comment: Repurposed clinical candidate for asthma (Phase 3).
Disease: Idiopathic pulmonary fibrosis
Ligand association comment: Repurposed clinical candidate for IPF (Phase 2).
Target: signal transducer and activator of transcription 3 (STAT transcription factors)
Receptor Immuno Comment: repurposed drug) inhibits binding of pSTAT3 to DNA. It has reached Phase 2 clinical development
Target: A2A receptor (Adenosine receptors)
Receptor Immuno Comment: repurpose A2A receptor antagonists that have failed late stage clinical trials (Phase 3) as Parkinson
Ligand: SR8185
Immuno Ligand Comments: developed for their anticancer potential, may be suitable for repurposing as clinical agents for autoimmune diseases.
Ligand: iguratimod
Bioactivity comments: iguratimod to be suitable as a candidate for drug repurposing to MIF-relevant diseases , including multiple sclerosis.
Ligand: arbekacin
Clinical use: repurposing effort, with the compound now being evaluated in clinical trial as a treatment for Duchenne
Ligand: thiabendazole
Clinical use: also have anti-angiogenic actions , with potential to be repurposed as an anti-tumor therapy.

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