basigin (Ok blood group) | CD molecules | IUPHAR/BPS Guide to PHARMACOLOGY

Top ▲

basigin (Ok blood group)

target has curated data in GtoImmuPdb

Target id: 3127

Nomenclature: basigin (Ok blood group)

Systematic Nomenclature: CD147

Family: CD molecules

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 268 19p13.3 BSG basigin (Ok blood group)
Gene and Protein Information Comments
Multiple transcript variants encoding different isoforms have been reported for this gene. The most prevalent is Oka (OK1, the 269 aa form). OK2 and OK3 are alternate isoforms.
Previous and Unofficial Names
basigin (Ok blood group | CD147 | Extracellular matrix metalloproteinase inducer (EMMPRIN)
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia

Download all structure-activity data for this target as a CSV file

Antibodies
Key to terms and symbols Click column headers to sort
Antibody Sp. Action Value Parameter Reference
meplazumab Hs Binding - -
Immunopharmacology Comments
CD147 might induce the production of pro-inflammatory cytokines such as IL-6 in monocytes [1]. Meplazumab (Jiangsu Pacific Meinuoke Bio Pharmaceutical) is a clinical stage anti-CD147 monoclonal that is being repurposed for COVID-19 pneumonia. In this setting it has potential to both inhibit viral entry into host cells via CD147, and to block CD147-mediated inflammatory signalling.
General Comments
Basigin (CD147) is a multi-functional immunoglobulin superfamily protein that is widely expressed (e.g. in epithelial cells, endothelial cells and leukocytes). It has metalloproteinase-inducing ability, and regulates biological processes including spermatogenesis, expression of the monocarboxylate transporter and the responsiveness of lymphocytes. Endogenous ligands include cyclophilins [2] and some integrins.

Basigin is exploited by the merozoite stage of Plasmodium falciparum to invade erythrocytes. CD147 neutralising antibodies can block merozoite invasion of host erythrocytes [3], indcating the potential of basigin as a novel malarial drug target in the host. Meplazumab (Jiangsu Pacific Meinuoke Bio Pharmaceutical) is a clinical stage anti-CD147 monoclonal that is being investigated for potential as both prophylaxis and treatment of malaria.

References

Show »

1. Redzic JS, Armstrong GS, Isern NG, Jones DN, Kieft JS, Eisenmesser EZ. (2011) The retinal specific CD147 Ig0 domain: from molecular structure to biological activity. J. Mol. Biol., 411 (1): 68-82. [PMID:21620857]

2. Yurchenko V, Constant S, Bukrinsky M. (2006) Dealing with the family: CD147 interactions with cyclophilins. Immunology, 117 (3): 301-9. [PMID:16476049]

3. Zenonos ZA, Dummler SK, Müller-Sienerth N, Chen J, Preiser PR, Rayner JC, Wright GJ. (2015) Basigin is a druggable target for host-oriented antimalarial interventions. J. Exp. Med., 212 (8): 1145-51. [PMID:26195724]

How to cite this page

CD molecules: basigin (Ok blood group). Last modified on 12/06/2020. Accessed on 10/07/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=3127.