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Esophageal cancer

Disease ID:336
Name:Esophageal cancer
Associated with:4 targets
Database Links
Disease Ontology: DOID:5041
OMIM: 133239


References:  1
Comments:  FZD7 has been implcated in esophageal carcimoma.
References:  2,4
Retinoic acid receptor-β
Role:  Esophageal cancer is associated with RARb loss-of expression.
References:  3
transforming growth factor beta receptor 2


No ligand related data available for Esophageal cancer


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1. Ishida K, Iwahashi M, Nakamori M, Nakamura M, Yokoyama S, Iida T, Naka T, Nakamura Y, Yamaue H. (2009) High CCR7 mRNA expression of cancer cells is associated with lymph node involvement in patients with esophageal squamous cell carcinoma. Int J Oncol, 34 (4): 915-22. [PMID:19287948]

2. King TD, Zhang W, Suto MJ, Li Y. (2012) Frizzled7 as an emerging target for cancer therapy. Cell Signal, 24 (4): 846-51. [PMID:22182510]

3. Qiu H, Zhang W, El-Naggar AK, Lippman SM, Lin P, Lotan R, Xu XC. (1999) Loss of retinoic acid receptor-beta expression is an early event during esophageal carcinogenesis. Am J Pathol, 155 (5): 1519-23. [PMID:10550308]

4. Tanaka S, Akiyoshi T, Mori M, Wands JR, Sugimachi K. (1998) A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals. Proc Natl Acad Sci USA, 95 (17): 10164-9. [PMID:9707618]