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This section gives an overview of the disease, and where available shows the following:
More information can be found in the help pages.
✖Disease ID: | 723 | |
Name: | Osteoporosis | |
Associated with: | 3 targets | |
1 immuno-relevant target |
Database Links |
Disease Ontology:
DOID:11476 OMIM: 166710 |
Click on the target name to link to its detailed view page
Where available, information is display on the role of the target in the disease; drugs which target the disease and their therapeutic use and side-effects.
If there is mutation data curated in GtoPdb this is indicated, with a link back to the appropriate section on the target detailed view page
Immuno ligand interactions - If available, a table of immuno-relevant ligands is shown. These ligands have been curated as having an association to the disease and possess interaction data with the target in GtoPdb. The approval status of the ligand is shown, along with curator comments and an indication of whether the target is considered the primary target of the ligand.
More information can be found in the help pages.
✖RXFP2 | |
Role: | Men with the T222P mutation of RXFP2 show a markedly increased susceptibility to osteoporosis a condition that is also displayed by RXFP2 knockout mice |
References: | 1 |
Estrogen-related receptor-α | |
Comments: | There is a statistical association between ERR alpha promoter polymorphism and lumbar spine Bone Mineral Density (BMD). |
References: | 2 |
regulator of G-protein signaling 10 | |
References: | 4 |
Click ligand name to view ligand summary page
Click the arrow in the final column to expand comments
More information can be found in the help pages.
✖No ligand related data available for Osteoporosis
1. Ferlin A, Pepe A, Gianesello L, Garolla A, Feng S, Facciolli A, Morello R, Agoulnik AI, Foresta C. (2009) New roles for INSL3 in adults. Ann N Y Acad Sci, 1160: 215-8. [PMID:19416191]
2. Laflamme N, Giroux S, Loredo-Osti JC, Elfassihi L, Dodin S, Blanchet C, Morgan K, Giguère V, Rousseau F. (2005) A frequent regulatory variant of the estrogen-related receptor alpha gene associated with BMD in French-Canadian premenopausal women. J Bone Miner Res, 20 (6): 938-44. [PMID:15883633]
3. Yang S, Hao L, McConnell M, Zhou X, Wang M, Zhang Y, Mountz JD, Reddy M, Eleazer PD, Li YP et al.. (2013) Inhibition of Rgs10 Expression Prevents Immune Cell Infiltration in Bacteria-induced Inflammatory Lesions and Osteoclast-mediated Bone Destruction. Bone Res, 1 (3): 267-281. [PMID:24761229]
4. Yang S, Li YP. (2007) RGS10-null mutation impairs osteoclast differentiation resulting from the loss of [Ca2+]i oscillation regulation. Genes Dev, 21 (14): 1803-16. [PMID:17626792]