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Disease ID:723
Associated with:3 targets
1 immuno-relevant target
Database Links
Disease Ontology: DOID:11476
OMIM: 166710


Role:  Men with the T222P mutation of RXFP2 show a markedly increased susceptibility to osteoporosis a condition that is also displayed by RXFP2 knockout mice
References:  1
Estrogen-related receptor-α
Comments:  There is a statistical association between ERR alpha promoter polymorphism and lumbar spine Bone Mineral Density (BMD).
References:  2
regulator of G-protein signaling 10
References:  4


No ligand related data available for Osteoporosis


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1. Ferlin A, Pepe A, Gianesello L, Garolla A, Feng S, Facciolli A, Morello R, Agoulnik AI, Foresta C. (2009) New roles for INSL3 in adults. Ann N Y Acad Sci, 1160: 215-8. [PMID:19416191]

2. Laflamme N, Giroux S, Loredo-Osti JC, Elfassihi L, Dodin S, Blanchet C, Morgan K, Giguère V, Rousseau F. (2005) A frequent regulatory variant of the estrogen-related receptor alpha gene associated with BMD in French-Canadian premenopausal women. J Bone Miner Res, 20 (6): 938-44. [PMID:15883633]

3. Yang S, Hao L, McConnell M, Zhou X, Wang M, Zhang Y, Mountz JD, Reddy M, Eleazer PD, Li YP et al.. (2013) Inhibition of Rgs10 Expression Prevents Immune Cell Infiltration in Bacteria-induced Inflammatory Lesions and Osteoclast-mediated Bone Destruction. Bone Res, 1 (3): 267-281. [PMID:24761229]

4. Yang S, Li YP. (2007) RGS10-null mutation impairs osteoclast differentiation resulting from the loss of [Ca2+]i oscillation regulation. Genes Dev, 21 (14): 1803-16. [PMID:17626792]