1. Bathgate RA, Lin F, Hanson NF, Otvos L, Guidolin A, Giannakis C, Bastiras S, Layfield SL, Ferraro T, Ma S, Zhao C, Gundlach AL, Samuel CS, Tregear GW, Wade JD. (2006) Relaxin-3: Improved Synthesis Strategy and Demonstration of Its High-Affinity Interaction with the Relaxin Receptor LGR7 Both In Vitro and In Vivo.
Biochemistry, 45: 1043-1053.
[PMID:16411781]
2. Büllesbach EE, Schwabe C. (2005) LGR8 signal activation by the relaxin-like factor.
J. Biol. Chem., 280 (15): 14586-90.
[PMID:15708846]
3. Del Borgo MP, Hughes RA, Bathgate RA, Lin F, Kawamura K, Wade JD. (2006) Analogs of insulin-like peptide 3 (INSL3) B-chain are LGR8 antagonists in vitro and in vivo.
J Biol Chem,: 727-729.
[PMID:16547350]
4. Ferlin A, Pepe A, Gianesello L, Garolla A, Feng S, Facciolli A, Morello R, Agoulnik AI, Foresta C. (2009) New roles for INSL3 in adults.
Ann. N. Y. Acad. Sci., 1160: 215-8.
[PMID:19416191]
5. Foresta C, Ferlin A. (2004) Role of INSL3 and LGR8 in cryptorchidism and testicular functions.
Reprod. Biomed. Online, 9 (3): 294-8.
[PMID:15353080]
6. Fu P, Shen PJ, Zhao CX, Scott DJ, Samuel CS, Wade JD, Tregear GW, Bathgate RA, Gundlach AL. (2005) Detection, localization, and action of the INSL3 receptor, LGR8, in rat kidney.
Ann. N. Y. Acad. Sci., 1041: 516-9.
[PMID:15956754]
7. Glister C, Satchell L, Bathgate RA, Wade JD, Dai Y, Ivell R, Anand-Ivell R, Rodgers RJ, Knight PG. (2013) Functional link between bone morphogenetic proteins and insulin-like peptide 3 signaling in modulating ovarian androgen production.
Proc. Natl. Acad. Sci. U.S.A., 110 (15): E1426-35.
[PMID:23530236]
8. Gorlov IP, Kamat A, Bogatcheva NV, Jones E, Lamb DJ, Truong A, Bishop CE, McElreavey K, Agoulnik AI. (2002) Mutations of the GREAT gene cause cryptorchidism.
Hum. Mol. Genet., 11 (19): 2309-18.
[PMID:12217959]
9. Halls ML, Bathgate RA, Summers RJ. (2006) Relaxin family peptide receptors RXFP1 and RXFP2 modulate cAMP signaling by distinct mechanisms.
Mol. Pharmacol., 70 (1): 214-26.
[PMID:16569707]
10. Halls ML, Bond CP, Sudo S, Kumagai J, Ferraro T, Layfield S, Bathgate RA, Summers RJ. (2005) Multiple binding sites revealed by interaction of relaxin family peptides with native and chimeric relaxin family peptide receptors 1 and 2 (LGR7 and LGR8).
J. Pharmacol. Exp. Ther., 313 (2): 677-87.
[PMID:15649866]
11. Harris RM, Finlayson C, Weiss J, Fisher L, Hurley L, Barrett T, Emge D, Bathgate RA, Agoulnik AI, Jameson JL. (2010) A missense mutation in LRR8 of RXFP2 is associated with cryptorchidism.
Mamm. Genome, 21 (9-10): 442-9.
[PMID:20963592]
12. Hombach-Klonisch S, Hoang-Vu C, Kehlen A, Hinze R, Holzhausen HJ, Weber E, Fischer B, Dralle H, Klonisch T. (2003) INSL-3 is expressed in human hyperplastic and neoplastic thyrocytes.
Int. J. Oncol., 22 (5): 993-1001.
[PMID:12684664]
13. Hossain MA, Rosengren KJ, Haugaard-Jönsson LM, Zhang S, Layfield S, Ferraro T, Daly NL, Tregear GW, Wade JD, Bathgate RA. (2008) The A-chain of human relaxin family peptides has distinct roles in the binding and activation of the different relaxin family peptide receptors.
J. Biol. Chem., 283 (25): 17287-97.
[PMID:18434306]
14. Hossain MA, Rosengren KJ, Samuel CS, Shabanpoor F, Chan LJ, Bathgate RA, Wade JD. (2011) The minimal active structure of human relaxin-2.
J. Biol. Chem., 286 (43): 37555-65.
[PMID:21878627]
15. Hsu SY, Nakabayashi K, Nishi S, Kumagai J, Kudo M, Sherwood OD, Hsueh AJ. (2002) Activation of orphan receptors by the hormone relaxin.
Science, 295 (5555): 671-4.
[PMID:11809971]
16. Kawamura K, Kumagai J, Sudo S, Chun SY, Pisarska M, Morita H, Toppari J, Fu P, Wade JD, Bathgate RA et al.. (2004) Paracrine regulation of mammalian oocyte maturation and male germ cell survival.
Proc. Natl. Acad. Sci. U.S.A., 101 (19): 7323-8.
[PMID:15123806]
17. Klonisch T, Müller-Huesmann H, Riedel M, Kehlen A, Bialek J, Radestock Y, Holzhausen HJ, Steger K, Ludwig M, Weidner W et al.. (2005) INSL3 in the benign hyperplastic and neoplastic human prostate gland.
Int. J. Oncol., 27 (2): 307-15.
[PMID:16010410]
18. Kubota Y, Temelcos C, Bathgate RA, Smith KJ, Scott D, Zhao C, Hutson JM. (2002) The role of insulin 3, testosterone, Müllerian inhibiting substance and relaxin in rat gubernacular growth.
Mol. Hum. Reprod., 8 (10): 900-5.
[PMID:12356938]
19. Kumagai J, Hsu SY, Matsumi H, Roh JS, Fu P, Wade JD, Bathgate RA, Hsueh AJ. (2002) INSL3/Leydig insulin-like peptide activates the LGR8 receptor important in testis descent.
J. Biol. Chem., 277 (35): 31283-6.
[PMID:12114498]
20. Muda M, He C, Martini PG, Ferraro T, Layfield S, Taylor D, Chevrier C, Schweickhardt R, Kelton C, Ryan PL et al.. (2005) Splice variants of the relaxin and INSL3 receptors reveal unanticipated molecular complexity.
Mol. Hum. Reprod., 11 (8): 591-600.
[PMID:16051677]
21. Overbeek PA, Gorlov IP, Sutherland RW, Houston JB, Harrison WR, Boettger-Tong HL, Bishop CE, Agoulnik AI. (2001) A transgenic insertion causing cryptorchidism in mice.
Genesis, 30 (1): 26-35.
[PMID:11353515]
22. Scott DJ, Fu P, Shen PJ, Gundlach A, Layfield S, Riesewijk A, Tomiyama H, Hutson JM, Tregear GW, Bathgate RA. (2005) Characterization of the rat INSL3 receptor.
Ann. N. Y. Acad. Sci., 1041: 13-6.
[PMID:15956681]
23. Shabanpoor F, Bathgate RA, Hossain MA, Giannakis E, Wade JD, Hughes RA. (2007) Design, synthesis and pharmacological evaluation of cyclic mimetics of the insulin-like peptide 3 (INSL3) B-chain.
J. Pept. Sci., 13 (2): 113-20.
[PMID:17120268]
24. Shabanpoor F, Hughes RA, Bathgate RA, Zhang S, Scanlon DB, Lin F, Hossain MA, Separovic F, Wade JD. (2008) Solid-phase synthesis of europium-labeled human INSL3 as a novel probe for the study of ligand-receptor interactions.
Bioconjug. Chem., 19 (7): 1456-63.
[PMID:18529069]
25. Shabanpoor F, Zhang S, Hughes RA, Hossain MA, Layfield S, Ferraro T, Bathgate RA, Separovic F, Wade JD. (2011) Design and development of analogues of dimers of insulin-like peptide 3 B-chain as high-affinity antagonists of the RXFP2 receptor.
Biopolymers, 96 (1): 81-7.
[PMID:20560146]
26. Shen PJ, Fu P, Phelan KD, Scott DJ, Layfield S, Tregear GW, Bathgate RA, Gundlach AL. (2005) Restricted expression of LGR8 in intralaminar thalamic nuclei of rat brain suggests a role in sensorimotor systems.
Ann. N. Y. Acad. Sci., 1041: 510-5.
[PMID:15956753]
27. Sudo S, Kumagai J, Nishi S, Layfield S, Ferraro T, Bathgate RA, Hsueh AJ. (2003) H3 relaxin is a specific ligand for LGR7 and activates the receptor by interacting with both the ectodomain and the exoloop 2.
J. Biol. Chem., 278 (10): 7855-62.
[PMID:12506116]
28. Xue K, Kim JY, Liu JY, Tsang BK. (2014) Insulin-like 3-induced rat preantral follicular growth is mediated by growth differentiation factor 9.
Endocrinology, 155 (1): 156-67.
[PMID:24169563]
29. Zhang S, Hughes RA, Bathgate RA, Shabanpoor F, Hossain MA, Lin F, van Lierop B, Robinson AJ, Wade JD. (2010) Role of the intra-A-chain disulfide bond of insulin-like peptide 3 in binding and activation of its receptor, RXFP2.
Peptides, 31 (9): 1730-6.
[PMID:20570702]