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Ovarian cancer

Disease ID:724
Name:Ovarian cancer
Associated with:7 targets
1 immuno-relevant target
Database Links
Disease Ontology: DOID:2394
OMIM: 167000


References:  3
References:  5
Mutations:  ADGRB1 is associated with 1 mutation. Click here for details
References:  5
Mutations:  ADGRB3 is associated with 1 mutation. Click here for details
References:  6
Mutations:  PKR1 is associated with 1 mutation. Click here for details
erb-b2 receptor tyrosine kinase 2
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
regulator of G-protein signaling 10


No ligand related data available for Ovarian cancer


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1. Altman MK, Alshamrani AA, Jia W, Nguyen HT, Fambrough JM, Tran SK, Patel MB, Hoseinzadeh P, Beedle AM, Murph MM. (2015) Suppression of the GTPase-activating protein RGS10 increases Rheb-GTP and mTOR signaling in ovarian cancer cells. Cancer Lett, 369 (1): 175-83. [PMID:26319900]

2. Cacan E, Ali MW, Boyd NH, Hooks SB, Greer SF. (2014) Inhibition of HDAC1 and DNMT1 modulate RGS10 expression and decrease ovarian cancer chemoresistance. PLoS ONE, 9 (1): e87455. [PMID:24475290]

3. Cheng S, Han L, Guo J, Yang Q, Zhou J, Yang X. (2014) The essential roles of CCR7 in epithelial-to-mesenchymal transition induced by hypoxia in epithelial ovarian carcinomas. Tumour Biol, 35 (12): 12293-8. [PMID:25168373]

4. Hooks SB, Murph MM. (2015) Cellular deficiency in the RGS10 protein facilitates chemoresistant ovarian cancer. Future Med Chem, 7 (12): 1483-9. [PMID:26293348]

5. Kan Z, Jaiswal BS, Stinson J, Janakiraman V, Bhatt D, Stern HM, Yue P, Haverty PM, Bourgon R, Zheng J, Moorhead M, Chaudhuri S, Tomsho LP, Peters BA, Pujara K, Cordes S, Davis DP, Carlton VE, Yuan W, Li L, Wang W, Eigenbrot C, Kaminker JS, Eberhard DA, Waring P, Schuster SC, Modrusan Z, Zhang Z, Stokoe D, de Sauvage FJ, Faham M, Seshagiri S. (2010) Diverse somatic mutation patterns and pathway alterations in human cancers. Nature, 466 (7308): 869-73. [PMID:20668451]

6. O'Hayre M, Vázquez-Prado J, Kufareva I, Stawiski EW, Handel TM, Seshagiri S, Gutkind JS. (2013) The emerging mutational landscape of G proteins and G-protein-coupled receptors in cancer. Nat Rev Cancer, 13 (6): 412-24. [PMID:23640210]