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Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
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More detailed introduction
Members of this RTK family represented a novel structural motif, when sequenced. The ligands for this family, growth arrest specific protein 6 (GAS6, Q14393) and protein S (PROS1, P07225), are secreted plasma proteins which undergo vitamin K-dependent post-translational modifications generating carboxyglutamate-rich domains which are able to bind to negatively-charged surfaces of apoptotic cells.
Axl (AXL receptor tyrosine kinase)
C
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Tyro3 (TYRO3 protein tyrosine kinase)
C
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Mer (MER proto-oncogene, tyrosine kinase)
C
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Database page citation:
Type XI RTKs: TAM (TYRO3-, AXL- and MER-TK) receptor family. Accessed on 07/07/2025. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=328.
Concise Guide to PHARMACOLOGY citation:
Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Catalytic receptors. Br J Pharmacol. 180 Suppl 2:S241-288.
AXL tyrosine kinase inhibitors have been described [1].