Top ▲ Transglutaminases

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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Transglutaminases catalyse an acyl transferase reaction of γ-carboxamide groups of glutamine residues (on the donor peptide) with ε-amino groups of lysine residues (on an acceptor peptide) which creates a crosslink between the two proteins. This enzymatic activity is calcium-dependent, and the bonds that are formed are highly resistant to proteolytic cleavage. Nine human transglutaminase-encoding genes have been identified, but only 8 are known to be enzymatically active.


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transglutaminase 2 Show summary » More detailed page go icon to follow link

How to cite this family page

Database page citation: Transglutaminases. Accessed on 02/12/2023. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes. Br J Pharmacol. 178 Suppl 1:S313-S411.