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ABCA subfamily C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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To date, 12 members of the human ABCA subfamily are identified. They share a high degree of sequence conservation and have been mostly related with lipid trafficking in a wide range of body locations. Mutations in some of these genes have been described to cause severe hereditary diseases related with lipid transport, such as fatal surfactant deficiency or harlequin ichthyosis. In addition, most of them are hypothesized to participate in the subcellular sequestration of drugs, thereby being responsible for the resistance of several carcinoma cell lines against drug treatment [1].

Transporters

ABC1, CERP (ABCA1) C Show summary » More detailed page

ABC2 (ABCA2) Show summary »

ABC3, ABCC (ABCA3) C Show summary »

ABCR (ABCA4) C Show summary »

ABCA5 C Show summary »

ABCA6 C Show summary »

ABCA7 C Show summary »

ABCA8 Show summary »

ABCA9 Show summary »

ABCA10 Show summary »

ABCA12 C Show summary » More detailed page

ABCA13 Show summary »

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References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation:

Mary Vore. ABCA subfamily. Accessed on 24/08/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=151.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2017) The Concise Guide to PHARMACOLOGY 2017/18: Transporters. Br J Pharmacol. 174 Suppl 1: S360-S446.