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Target not currently curated in GtoImmuPdb
Target id: 756
Nomenclature: ABCA1
Abbreviated Name: ABC1, CERP
Systematic Nomenclature: ABCA1
Family: ABCA subfamily
Gene and Protein Information ![]() |
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Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | 15 | 2261 | 9q31.1 | ABCA1 | ATP binding cassette subfamily A member 1 | |
Mouse | 15 | 2261 | 4 28.57 cM | Abca1 | ATP-binding cassette, sub-family A member 1 | |
Rat | - | - | Abca1 | ATP binding cassette subfamily A member 1 |
Database Links ![]() |
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Alphafold | O95477 (Hs), P41233 (Mm) |
ChEMBL Target | CHEMBL2362986 (Hs), CHEMBL1641361 (Mm) |
DrugBank Target | O95477 (Hs) |
Ensembl Gene | ENSG00000165029 (Hs), ENSMUSG00000015243 (Mm), ENSRNOG00000018126 (Rn) |
Entrez Gene | 19 (Hs), 11303 (Mm), 313210 (Rn) |
Human Protein Atlas | ENSG00000165029 (Hs) |
KEGG Gene | hsa:19 (Hs), mmu:11303 (Mm), rno:313210 (Rn) |
Pharos | O95477 (Hs) |
UniProtKB | O95477 (Hs), P41233 (Mm) |
Wikipedia | ABCA1 (Hs) |
Download all structure-activity data for this target as a CSV file
Inhibitors | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Inhibitor Comments | |||||||||||||||||||||||||||||||||||||||||||||||||||
Favari et al. (2005) report that probucol inhibits ABCA1-mediated cholesterol efflux from in vitro cultured mouse J774 cells by 80%, and from human fibroblasts by >50% [1]. |
Other Binding Ligands | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Immuno Process Associations | ||
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General Comments |
Loss-of-function mutations in ABCA1 are associated with Tangier disease, in which plasma HDL cholesterol levels are greatly reduced. ABCA1 is a key player in cholesterol efflux from macrophages to lipid-free apo-A1 in a process known as reverse cholesterol transport, a role that is important in atherosclerosis. ABCA1 also controls apoE lipidation, and has a role in Alzheimer's disease, including an impact on |
1. Favari E, Zanotti I, Zimetti F, Ronda N, Bernini F, Rothblat GH. (2004) Probucol inhibits ABCA1-mediated cellular lipid efflux. Arterioscler Thromb Vasc Biol, 24 (12): 2345-50. [PMID:15514211]
2. Koldamova R, Fitz NF, Lefterov I. (2014) ATP-binding cassette transporter A1: from metabolism to neurodegeneration. Neurobiol Dis, 72 Pt A: 13-21. [PMID:24844148]
3. Sethi AA, Stonik JA, Thomas F, Demosky SJ, Amar M, Neufeld E, Brewer HB, Davidson WS, D'Souza W, Sviridov D et al.. (2008) Asymmetry in the lipid affinity of bihelical amphipathic peptides. A structural determinant for the specificity of ABCA1-dependent cholesterol efflux by peptides. J Biol Chem, 283 (47): 32273-82. [PMID:18805791]
4. Wu CA, Tsujita M, Hayashi M, Yokoyama S. (2004) Probucol inactivates ABCA1 in the plasma membrane with respect to its mediation of apolipoprotein binding and high density lipoprotein assembly and to its proteolytic degradation. J Biol Chem, 279 (29): 30168-74. [PMID:15140889]